ID A0A1G1PES6_9BACT Unreviewed; 351 AA.
AC A0A1G1PES6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 10.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:OGX40357.1};
GN ORFNames=A3C53_06555 {ECO:0000313|EMBL:OGX40357.1};
OS Omnitrophica WOR_2 bacterium RIFCSPHIGHO2_02_FULL_68_15.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801861 {ECO:0000313|EMBL:OGX40357.1, ECO:0000313|Proteomes:UP000176809};
RN [1] {ECO:0000313|EMBL:OGX40357.1, ECO:0000313|Proteomes:UP000176809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGX40357.1}.
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DR EMBL; MHGU01000040; OGX40357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1PES6; -.
DR Proteomes; UP000176809; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 4: Predicted;
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT DOMAIN 3..345
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 351 AA; 38389 MW; 7F4B6798613AC9A5 CRC64;
MHKIAVIPGD GTGPEVVREG LKVLEAVARR TQVQYETVTY PFGGAHYLKT QETLPDAAIA
ELRRCSAIFL GAIGHPDVKP GILEREILLK LRFSLDQYIN LRPVKLYPGV WTPLKDKGPE
EIDFVVVREN TEDLYVGVGG FFKRGTPDEV ATQLSINTRK GVERCVRYAY QLTRARNKRK
KLTLCAKTNV LTYAHDLWLR TFEEVGREFP DITQEYTHVD ACCMWMVKSP ETFDVIVTTN
MFGDIITDLG AMIQGGMGIA AGGNLNPEGV SMFEPIGGSA PKYTGTGQIN PLAAIAAVGM
LLEHLGETEA GRQVEQAVMA VTATKLKSLA AGKMGCTTSQ VGDLVVEALN Q
//
