ID A0A1G1TH64_9BACT Unreviewed; 463 AA.
AC A0A1G1TH64;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:OGX90211.1};
DE Flags: Fragment;
GN ORFNames=BEN49_23500 {ECO:0000313|EMBL:OGX90211.1};
OS Hymenobacter coccineus.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1908235 {ECO:0000313|EMBL:OGX90211.1, ECO:0000313|Proteomes:UP000177506};
RN [1] {ECO:0000313|EMBL:OGX90211.1, ECO:0000313|Proteomes:UP000177506}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 8649 {ECO:0000313|EMBL:OGX90211.1,
RC ECO:0000313|Proteomes:UP000177506};
RA Sedlacek I., Kralova S., Kyrova K., Maslanova I., Stankova E., Vrbovska V.,
RA Nemec M., Bartak M., Svec P., Busse H.-J., Pantucek R.;
RT "Hymenobacter coccineus sp. nov., Hymenobacter lapidarius sp. nov. and
RT Hymenobacter glacialis sp. nov., isolated from Antarctic soil.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGX90211.1}.
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DR EMBL; MDZA01000179; OGX90211.1; -; Genomic_DNA.
DR RefSeq; WP_070743584.1; NZ_MDZA01000179.1.
DR AlphaFoldDB; A0A1G1TH64; -.
DR OrthoDB; 9809206at2; -.
DR Proteomes; UP000177506; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 158..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 181..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 230..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 267..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 304..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 343..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 378..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 7..404
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT NON_TER 463
FT /evidence="ECO:0000313|EMBL:OGX90211.1"
SQ SEQUENCE 463 AA; 49452 MW; D6264C1546E6C189 CRC64;
MSQLEPVIFL LALLVGLSAV APRLKLPYPV LLVAAGGLLA LLPLRAVVLS PDVVFLLFLP
PLLYEASFNM SWHDFVAYQR EISLLAVGLV LVTTTAVAAI AHFFIPGFSW PLGFVLGAIV
APPDAVAATS VTQGLGIPKK ITAILAGESL VNDASALIAY RYAVAAVVSG TFAFWDAAGQ
FFLVAGGGAL IGLALGWAVA AVQRRLAQPT LATAVTLLVP YVAYLLAERL GASGVLAVVF
MGLVISRRSH EIYDNRARLQ NNSFWQVFGF LLNGLVFILI GLQLRTVFTG LGPHAWLPTV
GYGLLISVVA VAIRLGWVFP VAFLMAFIHG WRRREATPVP MRALFITSWA GMRGVVSLAT
ALALPLAVAG GQPFPLRNVV LCITFVVILF TLVVQGLTLP WFVRRLHVQD APGVQTLEQQ
ELRLALIDDS VAYLGTRPAA DAAPAAVRDI LCGLLDGQAD RLR
//
