ID A0A1G1UXG2_9BACT Unreviewed; 562 AA.
AC A0A1G1UXG2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RCK N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51201};
GN ORFNames=A2782_01545 {ECO:0000313|EMBL:OGY07807.1};
OS Candidatus Blackburnbacteria bacterium RIFCSPHIGHO2_01_FULL_43_15b.
OC Bacteria; Candidatus Blackburnbacteria.
OX NCBI_TaxID=1797513 {ECO:0000313|EMBL:OGY07807.1, ECO:0000313|Proteomes:UP000177967};
RN [1] {ECO:0000313|EMBL:OGY07807.1, ECO:0000313|Proteomes:UP000177967}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY07807.1}.
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DR EMBL; MHBW01000035; OGY07807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1UXG2; -.
DR STRING; 1797513.A2782_01545; -.
DR Proteomes; UP000177967; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..533
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 562 AA; 60577 MW; F8322ED32763B3CF CRC64;
MSPLLVVAIG IGLAATLGFV ARMLRQPPLV GYIFAGMILS LFGFLLDGSS QSLYESMSTL
GITFLLFLVG LELNLNELKT LGRVIAIGGL GQILLTFTFA FLLGRALGFA TLEALYIGLA
LTFCSTIIIV KLLSEKKDMA SLYGKISVGV LLVQDLVVII VLVLLSGFRG DNPGLESIGL
VLVKGALLLT GIWALAKFVL TRVFDKIAVA SSELLFVSSI AWVLLVAAGV STPIVGFSPQ
MGGFLAGIAL ANSTGHLQIA SRVKPLRDFF ITIFFLLLGT KLVVGISTSL ILPAIVLSAF
VVIVNMFIVL TLMALLGHKK RTSFLIAVSF TQISEFSLIL VSLGQNLGHI SSSIVSLITL
VAVITMAVST YLILNGYWLY QKLNFLLRVF ELKKVRENAF TPTEKFAGHV VLLGCDRTGR
ALLPALKKLD CPFVIVDFNP AVVTRLVADG HNAYYADAAD TETLLSLGIN EAKMIISTTG
SLEDNLSVLE LLKSSKHQKK PISIFTAANP PDALRLYKDG ATYVVIPQTV GGEYLSGMID
SCGLEPDRYN KLRNRNIEQF AY
//
