ID A0A1G1WUD7_9BACT Unreviewed; 312 AA.
AC A0A1G1WUD7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Hydroxyacid dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=A3A57_00755 {ECO:0000313|EMBL:OGY31342.1};
OS Candidatus Woykebacteria bacterium RIFCSPLOWO2_01_FULL_41_12.
OC Bacteria; Candidatus Woykebacteria.
OX NCBI_TaxID=1802604 {ECO:0000313|EMBL:OGY31342.1, ECO:0000313|Proteomes:UP000179279};
RN [1] {ECO:0000313|EMBL:OGY31342.1, ECO:0000313|Proteomes:UP000179279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY31342.1}.
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DR EMBL; MHDA01000034; OGY31342.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1WUD7; -.
DR Proteomes; UP000179279; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 19..312
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..278
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 312 AA; 35099 MW; 4B0E4A563C592DBE CRC64;
MKFKKVLLIG ITESSLDKKY WKQLESSIEK KVFVEKDSAD IQMEITDADC LLLAFATSIT
KELLDKAPNL KYIGQFSTAF GKVDAGYAKS RGVSVANLPG FSTEAVAEFT IAAVLEFIRG
LEIGKQRGRK LNVDESGIKA WEIKGKKFGI IGLGRIGKRV GELAQTFGAE VLYWSRNKKQ
NPTFTYMDLD KLVATCDFLS LHLAQTPKTE KIMGVKRFMV LKPNCVVINT CPMELIDLDG
LCKRLAKKDI TFILDHADEM TKKDLEKLSR YENCIIYPPL AYITEEAKVN RQEMFVSNIE
NFLKGKPTNV VN
//
