ID A0A1G1WYI6_9BACT Unreviewed; 408 AA.
AC A0A1G1WYI6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
DE Flags: Fragment;
GN ORFNames=A3A61_01965 {ECO:0000313|EMBL:OGY32828.1};
OS Candidatus Woykebacteria bacterium RIFCSPLOWO2_01_FULL_43_14.
OC Bacteria; Candidatus Woykebacteria.
OX NCBI_TaxID=1802605 {ECO:0000313|EMBL:OGY32828.1, ECO:0000313|Proteomes:UP000177718};
RN [1] {ECO:0000313|EMBL:OGY32828.1, ECO:0000313|Proteomes:UP000177718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY32828.1}.
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DR EMBL; MHDB01000004; OGY32828.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1WYI6; -.
DR STRING; 1802605.A3A61_01965; -.
DR Proteomes; UP000177718; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 1..162
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT NON_TER 408
FT /evidence="ECO:0000313|EMBL:OGY32828.1"
SQ SEQUENCE 408 AA; 44050 MW; 034751215EC0F6E1 CRC64;
MGHVDHGKTS LLDAIRNSRV AEKEHGGITQ HIGAYQIDFK NQKITFIDTP GHAAFSQMRA
RGAQVTDLVI LVIAADDGVM PQTKESLSHI KASGVPFIIA ANKIDLPGAD INRIKQQLAE
NDVLVEEYGG NVPVVAVSAK TKQGLDDLLD MVILVCQVNE LKVSSKKEFV GVVIESKLDR
FRGPVATILV KSGVLKVGDQ ITAGNTRGKV RSLKLFDGKT TNQVVVSTPV EVMGLKEVPQ
VGEKVELSGS VDVAPIEAKE TKNIGFDFAD NSKKEFRLVI KADVAGSLEA IVRSIQELQT
PDSEVKFILK ETGDITESDI YLAQSTKALI IGFNVKPLPS AAKIAEREKV LIRTYSVIYE
LLDELKEGID VLTKKEAEPE IKGKASILAL FDTSSGTVVG ARVTEGEV
//
