ID   A0A1G1ZBK4_9BACT        Unreviewed;       566 AA.
AC   A0A1G1ZBK4;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=ACT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A3H06_01810 {ECO:0000313|EMBL:OGY61904.1};
OS   Candidatus Colwellbacteria bacterium RIFCSPLOWO2_12_FULL_44_13.
OC   Bacteria; Candidatus Colwellbacteria.
OX   NCBI_TaxID=1797694 {ECO:0000313|EMBL:OGY61904.1, ECO:0000313|Proteomes:UP000176976};
RN   [1] {ECO:0000313|EMBL:OGY61904.1, ECO:0000313|Proteomes:UP000176976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGY61904.1}.
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DR   EMBL; MHJC01000006; OGY61904.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G1ZBK4; -.
DR   Proteomes; UP000176976; Unassembled WGS sequence.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
FT   DOMAIN          37..135
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          381..446
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          491..566
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   566 AA;  65222 MW;  14BA76AA91ADEC1E CRC64;
     MTIEELIKTQ PHSLSRRAYD FAFKVHRGQK RLSGEPYFNH VVGTAQSLLD WRLDEVSIAA
     GLLHDVVEDS DYTIEDLQKE FGDEVAFLVD GVTKLGRLKY RGAERQVESL RKMILALSQD
     LRVVLIKLAD RLYNMRTLDA LPPHKQKRIA LETSEIYAPL AYRLGMQRLS GELQDLAFPY
     LYPQEHTWLR EQVKNRYHIR EAYLRRIAPK VEEALKEASI DILNIDFRAK RYSSLYKKLL
     RYEMDVDKIH DLIAFRIVVT SLPDCYNALG IIHQLFPPVP GRIKDYIALP KPNGYQSIHT
     TVFGPEQRAI EFQIRTQEMH DEAENGIAAH WAYEQTKGTG AYVKRTSSFA DMNDITWVHQ
     LRSWQEKFAD SEEFIESLKV DFFKDRIFCL TPQGEVVDLP LGSTPVDFAY QIHSEIGNQC
     VGARVNQKFV PLDYELSSSD VVEIAIQKNK KPSVSWLNFV KTSNARDHIR AVLRSSRSQN
     GLLRQAARES ELRLTVYDRP GLLRDIVETI SRSHVNVLSV TTNPISKSRL QLFKIKCNTV
     NKEKLQKLLL KLKGTKEVKE TSYLLS
//