ID A0A1G1ZKK1_9BACT Unreviewed; 499 AA.
AC A0A1G1ZKK1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN ORFNames=A3A16_00435 {ECO:0000313|EMBL:OGY65153.1};
OS Candidatus Harrisonbacteria bacterium RIFCSPLOWO2_01_FULL_44_18.
OC Bacteria; Candidatus Harrisonbacteria.
OX NCBI_TaxID=1798407 {ECO:0000313|EMBL:OGY65153.1, ECO:0000313|Proteomes:UP000177942};
RN [1] {ECO:0000313|EMBL:OGY65153.1, ECO:0000313|Proteomes:UP000177942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY65153.1}.
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DR EMBL; MHJJ01000014; OGY65153.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1ZKK1; -.
DR STRING; 1798407.A3A16_00435; -.
DR Proteomes; UP000177942; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07957; Anticodon_Ia_Met; 1.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039}.
FT DOMAIN 136..372
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 390..495
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 499 AA; 56873 MW; B10A7DCEEE859D3A CRC64;
MKKFYITTSI VYVNAPPHVG FALESIQADV LARYHRQKGD EVFFLTGADE HGAKIARAAE
AVGKDFQLFV DEIAAKVKKL KDVLNLSWDD FIRTTDKKRH WPGAQKLWRD MAAAGDLYRR
KYRGLYCVGH EAFVTEKDLI DGKCRDHQKE PEVIEEENWF FRLSKYQKKI ESSIKKNKLR
IIPEGRRTEV LSFIKEGLED VSFSRPRKDL SWGISVPDDE TSTMYVWCDA LANYISAIGY
GQQKSSPPKA DPPQAEKFTK WWPADIHLIG KDILRFHALL WPAMLLSAKL PLPKNIFVHG
HLTVDGQKMS KSVGNVVDPF ELVAKYGIDP ARYYLLREIP SGEDGDFSYK KLKERYNGDL
ANGLGNFAAR VLTLAEKLGE IKVDLKSDVD KAVAKKIKAV QKKVDEKITE FKLHEALAEI
WDLIAFGDKY VNEKKPWNAS LSVNEKARTI FNLIAILDNV AAMLSPFLPE TSKKITESIH
WLSKNTLKIK KSAMLFPRI
//
