ID A0A1G2CBL1_9BACT Unreviewed; 562 AA.
AC A0A1G2CBL1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RCK N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51201};
GN ORFNames=A2855_02025 {ECO:0000313|EMBL:OGY98606.1};
OS Candidatus Liptonbacteria bacterium RIFCSPHIGHO2_01_FULL_57_28.
OC Bacteria; Candidatus Liptonbacteria.
OX NCBI_TaxID=1798647 {ECO:0000313|EMBL:OGY98606.1, ECO:0000313|Proteomes:UP000179059};
RN [1] {ECO:0000313|EMBL:OGY98606.1, ECO:0000313|Proteomes:UP000179059}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY98606.1}.
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DR EMBL; MHKX01000005; OGY98606.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2CBL1; -.
DR STRING; 1798647.A2855_02025; -.
DR Proteomes; UP000179059; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..526
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 562 AA; 61622 MW; 094FA7BB74341153 CRC64;
MQGILTQITA LLGVTVGAAL IAKFLRQPII VAYIFAGIVA GPLFLNLVHG EREIFHIFSQ
LGVILLLFMI GLSLNFNYLR RIGKVAVAGG LAQVIFTGVI GMGILRAMGF AFMPALYLAV
AITFSSTIII TKLLSDKKDT DSLYGRHTVG LMLVQDLVAV LLMVFLTAQG GSMTISSSLI
RLALGGLVFI VGVTLLARYI LPPILRRIAD SKEFLFLFAI AWCFALAYAA SRFGFSIEIG
AVAAGLALGS STYQPEISAR ITPLRDFFLI IFFVILGAEM SLAAASTVFL PSVILSLFIL
IGNPLILYVV YRLMKFSRRN SLMIGLTAAQ VSEFGFVLLF IGRELGYVGE SEIASFTMVA
LATIFVSSYL ITHNGKIAGA VQNFLAKFSE ENHPQREEKP PVYDAWVIGY HRIGWNIVQV
LKEKKRSFAV IDFDPTVIEH LTKEGVPAYF LDVSDVGLLS ELPLDRARLV ISTIPDIQDQ
VTLLKHVRLH SAHTVIVANA PEAKFMRTLY EAGADYVMTP HLLGGKWIGH MISDGKASRA
AFRKLKKEQQ EEIRSGMPVQ EL
//
