ID A0A1G2CES8_9BACT Unreviewed; 306 AA.
AC A0A1G2CES8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 22-FEB-2023, entry version 10.
DE RecName: Full=Dehydrogenase E1 component domain-containing protein {ECO:0000259|Pfam:PF00676};
GN ORFNames=A2945_02730 {ECO:0000313|EMBL:OGY99884.1};
OS Candidatus Liptonbacteria bacterium RIFCSPLOWO2_01_FULL_52_25.
OC Bacteria; Candidatus Liptonbacteria.
OX NCBI_TaxID=1798650 {ECO:0000313|EMBL:OGY99884.1, ECO:0000313|Proteomes:UP000178880};
RN [1] {ECO:0000313|EMBL:OGY99884.1, ECO:0000313|Proteomes:UP000178880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGY99884.1}.
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DR EMBL; MHLA01000013; OGY99884.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2CES8; -.
DR STRING; 1798650.A2945_02730; -.
DR Proteomes; UP000178880; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 33..230
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 306 AA; 34310 MW; C322911DC7280D82 CRC64;
MYKQKIAEEI IRLRLSQMIV NEEHKKGQFK IPLHLAMGHE AIAVAVSEIM QDDDFLLPTH
RNMAYNLARA GSLRPILHEY LLKPTGLNGG RSGSMNLLNP ARGIVYTSSI LGNQFPVAVG
LAMAGKIFKK NRVTIVMGGD GSIEEGTFYE SMLMARSLNL PVIFIIENND WSMSTRIHER
RSPIDLSLFA ESLDIRYVHL EGNNPYLYVD VLKDLRKFSL ENSVPVCVEV KVSTLGVFSF
KTLEHPEGEP LHPHMGSTPA VSLDKGPMIE ESEKDPVFVL TKLIGRPTME EIARKQRAAI
EKEIET
//
