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Database: UniProt
Entry: A0A1G2EXL0_9BACT
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Original site: A0A1G2EXL0_9BACT 
ID   A0A1G2EXL0_9BACT        Unreviewed;       413 AA.
AC   A0A1G2EXL0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A2931_04545 {ECO:0000313|EMBL:OGZ30252.1};
OS   Candidatus Niyogibacteria bacterium RIFCSPLOWO2_01_FULL_45_48.
OC   Bacteria; Candidatus Niyogibacteria.
OX   NCBI_TaxID=1801724 {ECO:0000313|EMBL:OGZ30252.1, ECO:0000313|Proteomes:UP000177486};
RN   [1] {ECO:0000313|EMBL:OGZ30252.1, ECO:0000313|Proteomes:UP000177486}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|RuleBase:RU004135}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004135}.
CC   -!- SIMILARITY: Belongs to the MurCDEF family. MurE subfamily.
CC       {ECO:0000256|ARBA:ARBA00005898}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGZ30252.1}.
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DR   EMBL; MHMQ01000024; OGZ30252.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G2EXL0; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000177486; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004326; F:tetrahydrofolylpolyglutamate synthase activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR   Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR   InterPro; IPR018109; Folylpolyglutamate_synth_CS.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
DR   NCBIfam; TIGR01085; murE; 1.
DR   PANTHER; PTHR23135; MUR LIGASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR23135:SF4; UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE MURE HOMOLOG, CHLOROPLASTIC; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR   SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR   PROSITE; PS01011; FOLYLPOLYGLU_SYNT_1; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|RuleBase:RU004135};
KW   Cell division {ECO:0000256|RuleBase:RU004135};
KW   Cell shape {ECO:0000256|RuleBase:RU004135};
KW   Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU004135};
KW   Peptidoglycan synthesis {ECO:0000256|RuleBase:RU004135}.
FT   DOMAIN          44..202
FT                   /note="Mur ligase central"
FT                   /evidence="ECO:0000259|Pfam:PF08245"
FT   DOMAIN          247..331
FT                   /note="Mur ligase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02875"
SQ   SEQUENCE   413 AA;  46034 MW;  D61111312A2B2E83 CRC64;
     MNFTKKFIPG PVLDFLRPIY HRLFSVLSVV FYGRPSREMV VVGITGTNGK TSVVEYITQI
     LREAGIKTAS VSSLYFRIGD EAEKNTLKMT MPGRFFLQKF LRRALKAGCT HAVLEITSEG
     IRQFRHKNID WDVLVLTNIT PEHIESHGSF ENYRKAKEKV FAELSKTYCK SDVAKTFIIN
     GDDPAAPEFL KYEADKKIIY SKKDAPRELK LLGEFNLYNI AAAVKTAQAL GIPQEVITKA
     VEKIEGVPGR MEFVQREPFV VVVDYAHTPD ALRKVYETLR PPASGRLICV LGSAGGGRDK
     WKRPEMGKIA SEFCQEIILT NEDPYDEKPE VIIEDIFGGI AGIRSPGILG SNPGVLEIID
     RKEAIKKAIS DAKTGDVVVI TGKGAEPWIM GPGGTKTPWD DREIAREALK NKE
//
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