ID A0A1G2G7P1_9BACT Unreviewed; 493 AA.
AC A0A1G2G7P1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN ORFNames=A2756_06515 {ECO:0000313|EMBL:OGZ46226.1};
OS Candidatus Ryanbacteria bacterium RIFCSPHIGHO2_01_FULL_48_27.
OC Bacteria; Candidatus Ryanbacteria.
OX NCBI_TaxID=1802115 {ECO:0000313|EMBL:OGZ46226.1, ECO:0000313|Proteomes:UP000177785};
RN [1] {ECO:0000313|EMBL:OGZ46226.1, ECO:0000313|Proteomes:UP000177785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|RuleBase:RU003953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGZ46226.1}.
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DR EMBL; MHNL01000001; OGZ46226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2G7P1; -.
DR STRING; 1802115.A2756_06515; -.
DR Proteomes; UP000177785; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 1.10.246.80; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR46173; CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46173:SF1; CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-binding {ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953}.
FT DOMAIN 258..372
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 493 AA; 56279 MW; 009447B2D4E0BE96 CRC64;
MAFNIPKEIQ DIASVLDADG HEGYLVGGCV RDLLLDESPH DWDIATDARP EDIQRLFPES
FYENKFGTVT VVTKSKHESL RHIEVTPYRT EAGYSDRRHP DAVEFARTLD DDLRRRDFTV
NAMAIKITAR SATASPQAKV IDLFGGGDDL KKKIIRSVGD PKARFTEDAL RLMRAVRLAT
TLGFEIEQRT ASTIKQEAAL IRFVAPERIR DELSKLMMAD KPERGFEFMR EFDLLVHIMP
EILEGYAVGQ NKHHIYTVWE HNLRALRCAA DKKWSLEVRM GALLHDVGKP QSKRGEGPDS
TFYGHEIIGS KMATRMLDRL KYPRQFVEKV SKLIYYHLFY YNVGEVTESS VRRLIRNVGA
EDMEDLIRVR VCDRIGSGVP KAEPYKLRHF RFLVEKLSRD PISVGMLRVR GDDVMRIAKI
SPGPKIGFLL NILLEEVLDD PMRNKKSYLE GRLEELGAMS DAELKALADE AKKKAVAVEE
AKVGEIKKRH WVK
//
