ID A0A1G2JD31_9BACT Unreviewed; 736 AA.
AC A0A1G2JD31;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=A2401_02785 {ECO:0000313|EMBL:OGZ84330.1};
OS Candidatus Staskawiczbacteria bacterium RIFOXYC1_FULL_38_18.
OC Bacteria; Candidatus Staskawiczbacteria.
OX NCBI_TaxID=1802229 {ECO:0000313|EMBL:OGZ84330.1, ECO:0000313|Proteomes:UP000177751};
RN [1] {ECO:0000313|EMBL:OGZ84330.1, ECO:0000313|Proteomes:UP000177751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGZ84330.1}.
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DR EMBL; MHPP01000019; OGZ84330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2JD31; -.
DR STRING; 1802229.A2401_02785; -.
DR Proteomes; UP000177751; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 77..246
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 334..639
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 736 AA; 82205 MW; E22B6EFC62902753 CRC64;
MAKKNFPLKN LKEFLARHNI KKYLAYFCLT GFLFFVLLFF YYTWDLPKPE KFTETPFIQS
TKIYDRTGRV VLYDIFGEEK RQIVPFNKIS DHLKQAVLTS EDARFYQHGG IDFEGILRAV
WVDLLSQARS QGGSTITQQL IRTVYLTGQK SISRKIREIV LSIELEQKYS KDQIFEWYLN
AIPFGENAYG AESASQTYFS KPASDLSLAQ AATLTSLIPA PSHYSPYGPN KAELLQKKDS
VLERMKKNGY ITTEEMEEAK KEKIVFSETT NSIKAPDFVL YIKKYLDDKY GEDYLRERGL
RIYSTLDWDL QQYMEKTIKE SDKSLKSKNA NNAAAAAINP KTGEILALVG SKDYFAKPYP
EGCDEKGPNA CLFAPKYDVA TMGKRQPGSS FKPIVYATAF KKGFTPNTIL WDVNTEFNPN
CPPDGTGITD QYGLKCYSPQ DYDGGNRGPV TMRQALDQSL NIPAVETLYL TGIYDSLQTA
RDLGITTLTD INNYGLSLVL GGGDVNLLEM TSAYGVFAAE GIYIPPISIL KITDSDGNII
EENKKQPTKV LDTQIARTVN NVLSDNNARA PIFGFNSPLY FPNYQVAAKT GTTQNFVDGW
TMGYAPSIAV GVWVGNNNNV PTRDEGIGLA APIWHKIMEK VLLSQPAENF NPPEPITTGR
NPALLGQLPT GDTNTILYYV DKNNPLGSSP QNPASDPQYF MWQAAINNWL SKNNTALNSI
DTASNSTNKT VDVKLP
//
