ID A0A1G2KTZ2_9BACT Unreviewed; 663 AA.
AC A0A1G2KTZ2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:OHA02654.1};
GN ORFNames=A3J58_02905 {ECO:0000313|EMBL:OHA02654.1};
OS Candidatus Sungbacteria bacterium RIFCSPHIGHO2_02_FULL_52_23.
OC Bacteria; Candidatus Sungbacteria.
OX NCBI_TaxID=1802274 {ECO:0000313|EMBL:OHA02654.1, ECO:0000313|Proteomes:UP000178510};
RN [1] {ECO:0000313|EMBL:OHA02654.1, ECO:0000313|Proteomes:UP000178510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA02654.1}.
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DR EMBL; MHQM01000040; OHA02654.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2KTZ2; -.
DR STRING; 1802274.A3J58_02905; -.
DR Proteomes; UP000178510; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..274
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 317..649
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 663 AA; 72937 MW; 721E43F1D22D2978 CRC64;
MYARKYSWWS RFFLQSRRRR RRVLARGVEP DEIFMDAAVV SRDPIGAIEG KIERPLARFS
SFAFLACVGF GIVYLGVRGF ALQVASGADL FSKSQENRFA SRTLYAPRGI LRDRNGEALV
ENVPVYGLLF DRTSFLEGKG DLNVLKTRLS EILGEPAGAL TDLGFPEDGD VRKLPNRIFI
TRDMPLERMV VLAPHLDTLH GIEIFESFRR TYRDPRAFSH VLGYVGKVSP EEAAANTSLK
TEETVGKGGI ELFYDDALRG AGGEKIIETD SRGIETNYRL TREPASGDSL VLTLDGALQE
TAYRTIDRYS MHGHGASAVV LDVKNGAVRA LVSYPSFENG RLGQGLSADQ FQTLLRDPLT
PFFNRAIAGE FPSGSTIKPL IATAALEEHI IDPAKKIYDP GYIDIPNPYR PGESTRFPDW
RPQGWVDMYD AIAYSANVYF YIIGGGYQDQ KGLGISTIVR HARAFGLGER LGIDLPGEKA
GLVPDPEWKK TAEPEDPIWR IGDTYHVSIG QGGVKTTPLQ MAALTAAIAN GGTLWKPYLM
EGRYDSEGKL LESRSPEAIR TDLADQKSLK IVRQGMRETV LRGTARLLQN VPVAVAAKTG
TAQHAPGKPP HAWVVAFAPA ENPEIAVVVM VEQAGEGATV AVPITDEILR SYFSKNQEAS
IKN
//
