ID A0A1G2KVN3_9BACT Unreviewed; 801 AA.
AC A0A1G2KVN3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
DE Flags: Fragment;
GN ORFNames=A3J58_03635 {ECO:0000313|EMBL:OHA03460.1};
OS Candidatus Sungbacteria bacterium RIFCSPHIGHO2_02_FULL_52_23.
OC Bacteria; Candidatus Sungbacteria.
OX NCBI_TaxID=1802274 {ECO:0000313|EMBL:OHA03460.1, ECO:0000313|Proteomes:UP000178510};
RN [1] {ECO:0000313|EMBL:OHA03460.1, ECO:0000313|Proteomes:UP000178510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA03460.1}.
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DR EMBL; MHQM01000026; OHA03460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2KVN3; -.
DR STRING; 1802274.A3J58_03635; -.
DR Proteomes; UP000178510; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 34..207
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 298..585
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT NON_TER 801
FT /evidence="ECO:0000313|EMBL:OHA03460.1"
SQ SEQUENCE 801 AA; 87970 MW; 7F9FE855D3FF1409 CRC64;
MYALVRDLPN PSRLSERTVS ESTRIYDRTG EVLLYEIHGD QRRTVIPFED IPASVKQATL
VAEDINFYHH AGIDWRGIAR AIITNISRGN FSQGGSTITQ QFVKNSILGP EKTIQRKVRE
QILALLLERQ YSKDEIFGFY LNQIPYGSNA YGISAAADMY FAKKPADLTL AEAATIASLP
RAPSYYSPYG SHKDDLLKRK DWVLDRMAEA DFITREEADK AKTETLSFAL PHEAIRAPHF
VQHVRDYLNK EYGEDFVERG GLKVITTLDW KLQEEAEKIV REGAEGNDKL VKAANAALVS
IDPRTGDIIS MVGSRDYMAQ PIPAGCKPGV SCAFDPYVNI VTRERQPGSA FKPFVYATAF
KKGYTPETVL FDVFTEFNTS CNADGSPGPA INDPKNCYHP QDYDGQFRGP VSLRQAIAQS
LNVPAVKLLY LVGTKDAITT AQDMGITTLR DPDRYGLSLV LGGAEVTLLD ITSAFGVFAA
DGVRHAPSAI LRVETNKGIV LEEKKEEAPI PVLDTEIARV INDVLSDNDA RVPMFAPQSS
LFFPGRDVAA KTGTTQDYRD AWTIGYTPSV VTGVWVGNND NSPMNQKGLS VMVAGPIWHK
YMEAAISSHP PETFTPPEKD ISHDKPIFRG QYRSGPTVKI DKISRKLATD ATPPELIEEV
SFGAASSILA LIRKDDPLGD PPANPSSDLQ YANWQAGIDR WIGEHGSPLA TAPVEYDTLH
NQDTAPRISF VNPAPDAVSL PSLSDVAVQV LGSFPLREVS LFVDGVMVAA RTAPFVSFNI
SFPLNTPLHT GTHTLKISAY D
//
