ID A0A1G2LTC9_9BACT Unreviewed; 494 AA.
AC A0A1G2LTC9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 22-FEB-2023, entry version 13.
DE SubName: Full=B12-binding domain-containing radical SAM protein {ECO:0000313|EMBL:OHA14112.1};
GN ORFNames=A2909_02640 {ECO:0000313|EMBL:OHA14112.1};
OS Candidatus Tagabacteria bacterium RIFCSPLOWO2_01_FULL_39_11.
OC Bacteria; Candidatus Tagabacteria.
OX NCBI_TaxID=1802295 {ECO:0000313|EMBL:OHA14112.1, ECO:0000313|Proteomes:UP000178302};
RN [1] {ECO:0000313|EMBL:OHA14112.1, ECO:0000313|Proteomes:UP000178302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA14112.1}.
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DR EMBL; MHQZ01000017; OHA14112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2LTC9; -.
DR Proteomes; UP000178302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR025274; DUF4070.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034530; HpnP-like.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF3; HYPOTHETICAL METHYLTRANSFERASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13282; DUF4070; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00303; hopanoid_C2-methyltransferase; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 434..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 159..393
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 494 AA; 57328 MW; 857A7085F3291CD2 CRC64;
MKILFIYPEY PETFWSFKHA LKLINKKAAY PPLGLLTVAA MTPADWEKKL VDMNVEKLKE
KDLAWADYIF ISAMIVQKKS VREVIEKCKK MRKKIVAGGP LFTMDSEEYD DVNHLILGEA
ESNFSEFLDD LKNKRAKKIY ESKCLPGLSQ TPIPLWDLIK MKKYSSMNIQ YSRGCPYDCE
FCNITSLFGR LPRTKSVDQL LKEFDSLREI GWRGNVFVVD DNFMGNKVKL KKEILPGIID
WVERCKGPFN FSTEISINLA DDEELLGLMA KAGFEMVFIG IETPNEESLR ECNKFNNMGR
NLLASIQKIQ NYGLEVTAGF IVGFDNDPPS IFERQINFIQ KSGIVTAMVG LLNAPKGTRL
YQRLKNAGRI LEDAVSGDNT DYSMNFASKM EFRKLLEGYK NIVVSIYSPN QYYKRIAGFF
KEFRPLKLKK TGRFRLYYLV GFLKLMFYLG IKEKGRRAYW RFFIRTLIRH PRFFVHAMTF
AAFGLHFRKI FARD
//
