ID A0A1G2M3T9_9BACT Unreviewed; 185 AA.
AC A0A1G2M3T9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN ORFNames=A2664_03805 {ECO:0000313|EMBL:OHA17711.1};
OS Candidatus Taylorbacteria bacterium RIFCSPHIGHO2_01_FULL_46_22b.
OC Bacteria; Candidatus Taylorbacteria.
OX NCBI_TaxID=1802301 {ECO:0000313|EMBL:OHA17711.1, ECO:0000313|Proteomes:UP000178873};
RN [1] {ECO:0000313|EMBL:OHA17711.1, ECO:0000313|Proteomes:UP000178873}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001633};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA17711.1}.
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DR EMBL; MHRF01000013; OHA17711.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2M3T9; -.
DR STRING; 1802301.A2664_03805; -.
DR UniPathway; UPA00035; UER00043.
DR Proteomes; UP000178873; Unassembled WGS sequence.
DR GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR Pfam; PF00218; IGPS; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 4..100
FT /note="Indole-3-glycerol phosphate synthase"
FT /evidence="ECO:0000259|Pfam:PF00218"
SQ SEQUENCE 185 AA; 20584 MW; 22E45A44840BED87 CRC64;
MKQHPIDIIA EVKTVSPFGF ISDRSWEDLF RVAEEIGDMI SIHTDPRWGG SFELLEKARG
LTQKPILAKG IHKEDSDIRR AIECGADFVL VVGRMPSVYT SKCLIEPLSL AELKSIPLSQ
RAVWNSRDLA SGGLKKESFK DARAEFSEWL CQASNIQTVA DIDQSADAVL VGTHLIEFAE
SLINR
//
