ID A0A1G2PYH7_9BACT Unreviewed; 298 AA.
AC A0A1G2PYH7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=A2Z62_02610 {ECO:0000313|EMBL:OHA53377.1};
OS Candidatus Terrybacteria bacterium RIFCSPLOWO2_02_42_20.
OC Bacteria; Candidatus Terrybacteria.
OX NCBI_TaxID=1802370 {ECO:0000313|EMBL:OHA53377.1, ECO:0000313|Proteomes:UP000177649};
RN [1] {ECO:0000313|EMBL:OHA53377.1, ECO:0000313|Proteomes:UP000177649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA53377.1}.
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DR EMBL; MHTA01000035; OHA53377.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2PYH7; -.
DR STRING; 1802370.A2Z62_02610; -.
DR Proteomes; UP000177649; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..293
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 298 AA; 33989 MW; F11983F96FF3FB09 CRC64;
MKNIYKPYDE RHADFQYQGL LQNILESGIR AKSQQGIDAL TVLGPEPLRF HLNNGFPMIT
ERDVKSFWKQ AVGEICAFVN GARTQAELEK FGCKWWKSWV TKEKCEKRGL KEGDLGPGSY
GAAFHDFPTI QGKSFNQFAH IIEQIKELPH LRTHFISPWI PQYTGRGKGK NQKVVVAPCH
GWIHIRIIDN KLSLVMFQRS ADVPVGVPAN MIQYAALTLM IAHVTGYEPH QFIHMMSDAH
IYVDQILQVK QIISRNSKPF PTVNIDLTTD NLFDFRPEHF ALSDYNPHPA IKDIPVAV
//
