ID A0A1G2QCK0_9BACT Unreviewed; 560 AA.
AC A0A1G2QCK0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=A2114_02595 {ECO:0000313|EMBL:OHA57742.1};
OS Candidatus Vogelbacteria bacterium GWA1_51_14.
OC Bacteria; Candidatus Vogelbacteria.
OX NCBI_TaxID=1802435 {ECO:0000313|EMBL:OHA57742.1, ECO:0000313|Proteomes:UP000176494};
RN [1] {ECO:0000313|EMBL:OHA57742.1, ECO:0000313|Proteomes:UP000176494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA57742.1}.
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DR EMBL; MHTG01000007; OHA57742.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2QCK0; -.
DR STRING; 1802435.A2114_02595; -.
DR Proteomes; UP000176494; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..182
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 224..532
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 560 AA; 61109 MW; EB39A15A053951A4 CRC64;
MALIRWFKKM SRPRLRELDP DEIFLDSRNL PSFNTQQFEG QLEKPINKTV FYLFTIGVAV
VAGVLLGKVA LLQVVNGQAL AARSESNSLR HQIIFPERGI LYDRHGEELA WNDPDRLYIT
TPGFGHILGF IGYPTAEELT TTDFDHKELI GREGAEKLFN NQLAGAKGIK IEEINVGGGV
VSDHFLTMPE SGQSLVLSVD ADIQAELYQQ IKNLSEERGF AAGAGIIMDV TTGEIIALTS
YPDFDPNVMA TGTNREAINE YLTDPRSPFL NRAVSGLYTP GSIIKPFMAA AALAERVISP
DKTIVSTGQL VVPNPYNPEE PSIFKDWKAH GAVDMRRALA VSSNVYFYQI GGGFGGQAGL
GINKINEYVR LFGFGAPTGI NLTKENKGVI PSPEWKEENF PGQPWRLGDT YHTVIGQYGF
LVSPIQVVRA VAGISTGALV KPTLLKADGT ATTVAEPLPL ANSDLAVVRE GMRLAVTEGT
AQGLSLPAVR VAAKTGTAEL GTLKEDVNSW VIGFWPYEAP RYAFVVVMEK GSRSNLIGGV
AVMRRVLDWL AIYKPEYFSI
//
