ID A0A1G2R4S1_9BACT Unreviewed; 649 AA.
AC A0A1G2R4S1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:OHA67727.1};
GN ORFNames=A3C04_00365 {ECO:0000313|EMBL:OHA67727.1};
OS Candidatus Wildermuthbacteria bacterium RIFCSPHIGHO2_02_FULL_45_25.
OC Bacteria; Candidatus Wildermuthbacteria.
OX NCBI_TaxID=1802450 {ECO:0000313|EMBL:OHA67727.1, ECO:0000313|Proteomes:UP000178092};
RN [1] {ECO:0000313|EMBL:OHA67727.1, ECO:0000313|Proteomes:UP000178092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA67727.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MHTV01000005; OHA67727.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2R4S1; -.
DR Proteomes; UP000178092; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..266
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 307..641
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 649 AA; 72665 MW; 1C9D23D7B02CC5D5 CRC64;
MFRFPFLRNN KSSYYSQDEI EVQDIFLDKL AQDKESLESG YDEKKLEVPL SRWILRGIAC
VFALALLIFF GKTLYLQVVL GQELQEMAKE NTIRMLPLRP GRGIVYDASM VQLAFNKPSF
DFVCDKRYLP TNREKLDTVI RDIASYFSLS YEDLKEQLKN FEENEMLIAE NISHEQLILT
ETQEDKWQGC QSQQNTIRSY VTDAGLAHIL GYTAKISPEE LKNQDGYFVT DQIGKTGIEK
SYEAVLRGNP GLRFIKKDAR GNIVEDQGEV GSEAGGNVML WVDLELQKKM EVELKKSMEK
VGSKKAIAIA MDVNTGGVLG MVSIPSFDNN IFARGITEKE YQEIINNPTS PLFNRAIAGM
YPTGSAIKPL MALGALEEKV IDPNQNILTE GYLEIPNQYD PSIVYRFNDN KNHGWVDMRK
ALAVSSNVYF YIIGGGYKNL NGLGPSRIEQ YLSLFGWGKK TGIDLPGESD GLIPNPEWKQ
RVKKEGWWDG DTYQLSIGQG NLLATPLQVA SAFAAIANGG TLYEPQMVKA VIGNGKKVEE
YRPLVVKENI VKRENIQVVK EGLRQAVTSG SSTILNQVSV PVAAKTGTAQ TGRKDENGKD
YLYSWVAAFA PYDNPKIVIT VMVEDAKEGS IAVLPVAKDV LNWYFSNKQ
//
