ID A0A1G2SBN4_9BACT Unreviewed; 1067 AA.
AC A0A1G2SBN4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A3B07_02355 {ECO:0000313|EMBL:OHA82443.1};
OS Candidatus Yonathbacteria bacterium RIFCSPLOWO2_01_FULL_43_27.
OC Bacteria; Candidatus Yonathbacteria.
OX NCBI_TaxID=1802726 {ECO:0000313|EMBL:OHA82443.1, ECO:0000313|Proteomes:UP000178817};
RN [1] {ECO:0000313|EMBL:OHA82443.1, ECO:0000313|Proteomes:UP000178817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHA82443.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MHUV01000006; OHA82443.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2SBN4; -.
DR STRING; 1802726.A3B07_02355; -.
DR Proteomes; UP000178817; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..78
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1067 AA; 119869 MW; EF81DB0FF552FFCF CRC64;
MSTPSEQKSF IHLHTHSHYS LLDGLSKVEE MVALAKEYGM NAVGLTDHGN MYGAIDFYKT
CKKKGIKPII GVEAYMTPGS RHDKRPGIDT ERFHLTLLAK NEAGYKNLIR LVTISNLEGF
YYKPRIDKEV LRKYSNDLIC LSGCFGSEFS RAVRREDLEE AEKIAREHQE IFGAENYFLE
IMHHPGIEDF DKTRDHIIAL SKKLDIPLVA TQDSHYLHHE DQRAHETLLA IQTNGDLKDE
NRFSMAVDDF SFINTETALE YFKETPEAVW NTQKIADMCN IELTLGSWVF PDLKIPEGTD
YNSELKRLVY EGITTRGLDA NDSNVIDRIE YELKVIRDKG YAPYFLVVGD LLRFSRENNI
LTNIRGSVAG SITTYLLGIT NVNPLEYNLP FERFLNPERP SAPDIDMDYA DNRRDEVISY
ARQKYGSENV AQIGTFGTMM ARGAVRDVAR ALGHPYGIGD KISRLIPEGS QGFPMTIDTA
LSTVPELADL YKNDASTTEI IDLAKKLEGC VRHISVHAAG VVIGPKPLYE FTPTQLDPKG
GKIITQYDMH AVEDAGLLKF DFLGIRNLSI LGDAIRLVKE RHDVHIDLDH IPLDDPRTFA
MLARGETMGL FQLNGAGMTR YLKELRPTTI HDINAMVALY RPGPMESIPE YIKRKYNPST
ITYLDPRLKD ILAMSYGVIT YQDDVMMIAI HLAGYSWLDA DKLRKAMGKK IPAEMQAQKE
KLLKGFTEYG KLSKKVTEEL WALIEPFAAY GFNKAHAASY GRLAYQTAFM KANYPVEYMT
AILTAESGDT EKIAEIISES KRMSIPILPP DVNASFGGFT IVTKDDKEEI RFGLYTIKNL
GTDISDAVIA EREANGHYST LANFLERIRH KNLNKKSYEA LVMSGAMDGL GERGVMLANT
EEALAYNRAQ GEEMSGQASL FGQMTDTSTV PSLRLKSAPP AAKKEMLTWE KELLGLFVSG
HPLDAHREKL EAIGTTVEKV KTLRDGNVAV AGGIVEDIRS ILTKKGDKMA FVKLTDYSGT
LELVLFPEVF FTHKEFFETP DRCIKVKGKV SERNGEKSLI VERVKEL
//