ID A0A1G2VPB3_9BACT Unreviewed; 666 AA.
AC A0A1G2VPB3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=UvrABC system protein B {ECO:0000256|ARBA:ARBA00029504, ECO:0000256|RuleBase:RU003587};
GN ORFNames=A3I22_00340 {ECO:0000313|EMBL:OHB23363.1};
OS Parcubacteria group bacterium RIFCSPLOWO2_02_FULL_40_12.
OC Bacteria.
OX NCBI_TaxID=1817744 {ECO:0000313|EMBL:OHB23363.1, ECO:0000313|Proteomes:UP000177804};
RN [1] {ECO:0000313|EMBL:OHB23363.1, ECO:0000313|Proteomes:UP000177804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC lesions. Interacts with UvrC in an incision complex.
CC {ECO:0000256|ARBA:ARBA00026033, ECO:0000256|RuleBase:RU003587}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000256|ARBA:ARBA00008533,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHB23363.1}.
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DR EMBL; MHXI01000008; OHB23363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G2VPB3; -.
DR Proteomes; UP000177804; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd17916; DEXHc_UvrB; 1.
DR CDD; cd18790; SF2_C_UvrB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004807; UvrB.
DR InterPro; IPR041471; UvrB_inter.
DR InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR NCBIfam; TIGR00631; uvrb; 1.
DR PANTHER; PTHR24029; UVRABC SYSTEM PROTEIN B; 1.
DR PANTHER; PTHR24029:SF0; UVRABC SYSTEM PROTEIN B; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF12344; UvrB; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003587};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769,
KW ECO:0000256|RuleBase:RU003587};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003587};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881,
KW ECO:0000256|RuleBase:RU003587};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW SOS response {ECO:0000256|RuleBase:RU003587}.
FT DOMAIN 23..156
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 436..602
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 629..664
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT COILED 259..286
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 666 AA; 76887 MW; 05F58851B63606ED CRC64;
MFKLVSTYKP TGDQPKAIVK LIHGLKNGQK QMILLGVTGS GKTFTMANVI AELKKPTLVI
SHNKTLAAQL YQELKDFFPE NSVHYFVSYY DYYQPEAYLP HTDTYIEKDV KINQEIDRLR
HAATQALLTR NDVIIVASVS CIYNLGSPED YKNLSLEIFE GQKISLIEAV KSLSRLQYKK
DYEIKRGGFR NTKDEIEVFS ADGNNLHKII FNKNKIFKIY TAKVGHPDDV EFEKPNYQRI
LEAKIFPAKY WIAPDQKIDI ALENIKTELQ QTVQKLKKEG KGLESERLIQ RTLYDLRLIK
ETGYCHGIEN YSRHLDFRKP GAPPFTLLNF FKTKGDFLTI IDESHITIPQ LKGMHQGDKA
RKETLVEYGF RLPSALDNRP LHFEEFEKRI NRSVFVSATP SKHELKKAGK QGLVEQLIRP
TGLLDPTIEI RETKNQVKHL IEEVKRRIAK KERILVTTLT KRMAEDMAEY LADNGIKTNY
IHSEIKTLDR LEIIKGLRTG QYDVIVGVNL LREGLDLPEV SLIAIFDADK EGFLRNTTTL
IQTMGRAARH INGHIILYAD KTTRSMQTAI NETLRRRKTQ EDHNQKNNIT PQSIKKAIKD
YDLPIKRKRE KIYDELSTPI NPKAWYDISE IIKQLEKTMT KAVKELDFET ALTIREQILK
LKKNGK
//
