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Database: UniProt
Entry: A0A1G3CSH8_9BURK
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ID   A0A1G3CSH8_9BURK        Unreviewed;       831 AA.
AC   A0A1G3CSH8;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN   ORFNames=A2X74_00925 {ECO:0000313|EMBL:OHC10437.1};
OS   Polynucleobacter sp. GWA2_45_21.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=1801989 {ECO:0000313|EMBL:OHC10437.1, ECO:0000313|Proteomes:UP000176957};
RN   [1] {ECO:0000313|EMBL:OHC10437.1, ECO:0000313|Proteomes:UP000176957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: Participates in initiation and elongation during chromosome
CC       replication; it exhibits DNA-dependent ATPase activity and contains
CC       distinct active sites for ATP binding, DNA binding, and interaction
CC       with DnaC protein, primase, and other prepriming proteins.
CC       {ECO:0000256|ARBA:ARBA00003574, ECO:0000256|RuleBase:RU362085}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665,
CC         ECO:0000256|RuleBase:RU362085};
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHC10437.1}.
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DR   EMBL; MHZG01000001; OHC10437.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G3CSH8; -.
DR   STRING; 1801989.A2X74_00925; -.
DR   Proteomes; UP000176957; Unassembled WGS sequence.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00665; DnaB; 1.
DR   PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR   PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 2.
DR   Pfam; PF14528; LAGLIDADG_3; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR   SUPFAM; SSF55608; Homing endonucleases; 1.
DR   SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU362085};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU362085};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362085};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|RuleBase:RU362085};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          201..238
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   DOMAIN          356..499
FT                   /note="DOD-type homing endonuclease"
FT                   /evidence="ECO:0000259|PROSITE:PS50819"
FT   DOMAIN          591..820
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
SQ   SEQUENCE   831 AA;  92022 MW;  E316B5F266603888 CRC64;
     MAESRSRSLM SNPGMMGSGD AALQALKVPP HSVEAEQSLL GGLLIDNTAW DRLGGVLTDK
     DFYRPEHALI YKVIQRLVGD NHPADVITVH EAVKSEQGGD LVGIDYLNSL AQSTPSAANI
     KGYADIVRDR SILRRLIEVS DNIVNSAFVP EGRSVRTLLD EAESRILQIG EEGSRKADYL
     EIEPLLKTVV ARIDELYNRQ GGSDITGIAT GFIDLDKQTS GLQKGDLVIV AGRPSMGKAQ
     PLDAKVKTVD GWKLMGDLRF GDRLASVDGQ HSMVTGIYPQ GIKQIYKVTF SDGREAECCY
     EHLWRVMYRD WDAPKVINTA RLMEMLSCVR YKNRLWIDPV SGDFGHSNKL PINPWVLGAL
     LGDGTLALSH GSVMFSTKSP ELIERMNALA GYEMELVHAN AYDWRLVSKT RIAANGQRQS
     VPTNYFRSAL QDLGVLGCRS FDKYIPATYL EANKTSRLAL FQGLMDTDGW IEKWGSIRFC
     TASKQLSEDV ASLARSLGGF CSIAHKQTSY TYKGEKKQGR LSYVLNMSFG PGFQAFTLPE
     KKERLRSTWD RQRRLTFKSI EPSRVSEAQC ISVSHPDRTY VTNEYVVTHN TAFALNIAEN
     VALAEGLPVV VFSMEMSGEQ LAARLLGSVG RVDQGRMRTG KLQDDEWPRV TDAIARLSNT
     QILIDETGAL SSLELRARAR RIARNFGGTL GLVVIDYLQL MSGSGSENRA TEISEISRSL
     KSLAKELQCP VVALSQLNRG LEQRPNKRPI MSDLRESGAI EQDADLIMFI YRDEVYHPDT
     TTDKGMAEII IGKQRNGPIG TVRLSWQGPY TKFDNLAMGS VGYSSGGYEP F
//
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