ID A0A1G3L3B9_9SPIR Unreviewed; 392 AA.
AC A0A1G3L3B9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN ORFNames=A2Y41_07710 {ECO:0000313|EMBL:OHD12315.1};
OS Spirochaetes bacterium GWB1_36_13.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802174 {ECO:0000313|EMBL:OHD12315.1, ECO:0000313|Proteomes:UP000177420};
RN [1] {ECO:0000313|EMBL:OHD12315.1, ECO:0000313|Proteomes:UP000177420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD12315.1}.
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DR EMBL; MIAO01000055; OHD12315.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3L3B9; -.
DR STRING; 1802174.A2Y41_07710; -.
DR Proteomes; UP000177420; Unassembled WGS sequence.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 224..328
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 392 AA; 43890 MW; B71C4C961C8C6923 CRC64;
MGAITSTVIA GAAAINKGIA PALGSFTQLS EIEVKGKRTL VKDALSLTSF KDLVFGGWDI
EDITMYQRAL DCKVLEKDLV NQVREETEAV RTMPAVFDTK YVKRLEGSFV KKGKNWMDLA
EQVMKDIENF KAINKLERCV MIWNGSTEIY MEETAVHKSL KSFEEGMKNN SPEIAPSMIY
AYAALKMGIP YINGAPNLTI DFPAMLELAE LTQTPIMGKD WKTGQTLIKT VLAPGLKVRN
LQVEGWYSTN ILGNRDGLVL DDPSSFKTKE VSKLSVLGSI LGYEPYHKVT INYYPPRGDN
KEGWDNIDFN GFLGYPMQLK VDFLCRDSIL AAPLVLDTAL LADFAKQKGE KGIQKWLNFF
FKSPQVAKKG DIPIHDVFEQ HHVLVDKLKT MI
//
