ID A0A1G3MPJ5_9SPIR Unreviewed; 452 AA.
AC A0A1G3MPJ5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Aminopeptidase P N-terminal domain-containing protein {ECO:0000259|SMART:SM01011};
GN ORFNames=A2004_10260 {ECO:0000313|EMBL:OHD31919.1};
OS Spirochaetes bacterium GWC1_61_12.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802180 {ECO:0000313|EMBL:OHD31919.1, ECO:0000313|Proteomes:UP000178922};
RN [1] {ECO:0000313|EMBL:OHD31919.1, ECO:0000313|Proteomes:UP000178922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD31919.1}.
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DR EMBL; MIAU01000065; OHD31919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3MPJ5; -.
DR Proteomes; UP000178922; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF4; XAA-PRO AMINOPEPTIDASE 3; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 1..121
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 452 AA; 48319 MW; 82CF8490FF1C2551 CRC64;
MREAGVSVGL ILLPGNAESP MNYTDNTYRF RQDSAFLYCF GLAEPDMAAT IDVASGRTTL
YADELTVDML VWTGPRLGVA ALAAACAADD VQPSAALPCT LRAAAARDGL PLFLPPYRGE
TCLRLAAWLD VPAAMLADKA SLPLIKAMIA LRQIKEEREV EQIEQAVNTT IAMHRAVMAL
GTPGRSEAAL MAEATRVALA GGGMPSFPPI ATVRGAVLHN HGYPGYLRSG DLFLLDAGAE
TVMGYAGDLT TTFPVDGKYS PQQRAIYEIV LAAGKAAAGL LKPGLPFKEA HFAAARTIVE
GLQALGLMSG PLDEIIAAGA HALFFPHGLG HQMGLDVHDM ESLGEAQVGY DGQPKSTQFG
LKSLRLAKPL LAGMVLTIEP GIYFIEGLIA LWRAEGRFKQ YIHYDRLEPW LQAGGYRNEE
NWLIRADGAH LLGARFDKSV AGMETALAGR RS
//
