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Database: UniProt
Entry: A0A1G3MRM7_9SPIR
LinkDB: A0A1G3MRM7_9SPIR
Original site: A0A1G3MRM7_9SPIR 
ID   A0A1G3MRM7_9SPIR        Unreviewed;       385 AA.
AC   A0A1G3MRM7;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=A2004_02335 {ECO:0000313|EMBL:OHD32671.1};
OS   Spirochaetes bacterium GWC1_61_12.
OC   Bacteria; Spirochaetes.
OX   NCBI_TaxID=1802180 {ECO:0000313|EMBL:OHD32671.1, ECO:0000313|Proteomes:UP000178922};
RN   [1] {ECO:0000313|EMBL:OHD32671.1, ECO:0000313|Proteomes:UP000178922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OHD32671.1}.
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DR   EMBL; MIAU01000053; OHD32671.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000178922; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 2.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 2.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000178922};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       53    375       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   REGION        1     21       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      128    154       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    128    142       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   385 AA;  40303 MW;  3F4A99CAFD3E4809 CRC64;
     MPTGAEKPNP SHLLPESGNP AVRRLPTPGE LRAEFRLSAT AAAGIAASRQ TILDILAGRD
     RRLLTIVGPC SVHDAAEALA YGRWLQLQAT RHADCLFVVM RCFIEKSRTG AGWRGLVRSP
     LPATCLASQA DQAASPPTDA HATDRQQRPD DTAEGLRQAR DLLCQLAEHG LPLAVELVSP
     LLWPYWADCA SWVAVGARGV ESAALREAAS ALPCASGFKN ATDGQTDSAR LAVATALRPS
     TVLTVDEAGV LVELLSRGNP LPHVVLRGGR NGDNLVQAAP LAAQLAVDGL PAALLVDASH
     GNSGFRPETQ AGIVRCALEL RRQGLPVRGL LIESYLRSGA QPLDCGAPGT TSIGQRLQAG
     LSVTDPCLGQ AETASLLDEI AAALK
//
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