ID A0A1G3Q950_9SPIR Unreviewed; 760 AA.
AC A0A1G3Q950;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=HD/PDEase domain-containing protein {ECO:0000259|SMART:SM00471};
GN ORFNames=A2176_11550 {ECO:0000313|EMBL:OHD63202.1};
OS Spirochaetes bacterium RBG_13_51_14.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802193 {ECO:0000313|EMBL:OHD63202.1, ECO:0000313|Proteomes:UP000176595};
RN [1] {ECO:0000313|EMBL:OHD63202.1, ECO:0000313|Proteomes:UP000176595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD63202.1}.
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DR EMBL; MIBH01000075; OHD63202.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3Q950; -.
DR STRING; 1802193.A2176_11550; -.
DR Proteomes; UP000176595; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..689
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 760 AA; 86076 MW; 287CDF7753DA1F6C CRC64;
MKPYFNNAVR TVRQILENPN IKLSLITVLI IIFISTILLS INIFGVSYHY EVGDIADEDI
RVPRDIEYVN ETETAIDHKR EAEAVPIVFN KDASVLQRKL NITGALITHA AETLKQYPPT
GNDFTFQVYA MKSRMPKYLH FNDAILAELL RFRDHAKLKK IMSRILIYIY DDPRMGVLDK
PYDNPLKIYN NNVTVRTINS PETVDEVSRT LDSLKTMDDI NGNLFGICYS LEPYLQKPAL
TAITTIVGSF LEPNLFFNPE ESKRRITEAV KKVTPVTSKL KKGQTIVRDG DTITQDIQHK
IDIYNKQTAT INISYIFGIL LIQILFFAIF GFFLMEFNKI FLPDRKSTLI IFTLLIIFMV
YTFFISRIES PVNSRLTFPL MLPISFTTMI LSILYNRYLS IMVGIYIVFF TTIISGGSIS
TTMIAFSSAL VGVFVNEKVE MRTDFLRGGF IVGMINSILV ISVALIQEIP VLNTSFIMII
AIALANGIIN SILTLGILPL YENLFGITTK FRLLELSDLN ADIFKEMLMK APGTYNHSML
VSTMAEAACK EIGASHLLAR VGAYYHDIGK IADAGMYIEN RVTDPRAKYM SPLKYAQLII
SHVEKGVSLA AENELPDSVI SFIREHHGQT TMTFFYHQSL EDADTRSNEP ISKSDFQYPG
PKPHNKEAAV VMLADSIEAA ARSLQNPTYE KLDGLVRKIV YNKLNEGELE FSDLSMTELR
VVQDAFISLL KGIFHSRIEY PDDFDLKKLE KKQMRSDGSN
//
