ID A0A1G3QDN8_9SPIR Unreviewed; 802 AA.
AC A0A1G3QDN8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OHD64816.1};
GN ORFNames=A2176_10900 {ECO:0000313|EMBL:OHD64816.1};
OS Spirochaetes bacterium RBG_13_51_14.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802193 {ECO:0000313|EMBL:OHD64816.1, ECO:0000313|Proteomes:UP000176595};
RN [1] {ECO:0000313|EMBL:OHD64816.1, ECO:0000313|Proteomes:UP000176595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD64816.1}.
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DR EMBL; MIBH01000041; OHD64816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3QDN8; -.
DR STRING; 1802193.A2176_10900; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000176595; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..199
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 203..302
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 365..440
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 802 AA; 89040 MW; 29BBFE0676AAD589 CRC64;
MVRRIQKVAV IGSGIMGGGI AALCASAGIP TLLLDIVPFD LKDDEKKDPK ARNRIVSAGF
ENILKAKPAL FYDKDMDSQL VQLGNLEDDF NKLAECDWIV EVVVENLKIK QDLFSKIEKI
MKKGAIISTN TSGLPLNKIA QGRSKAFKEH FLGTHFFNPV RYMHMLEIIP GKETKKDILK
FIAEFGEKVL GKGIVWAKDT PNFIGNRIGV FSGVRAMQIM MEMKMTIPEV DALSGPAIGR
PKTASIKLLD LVGLDTFVHV ATNCYELCAN DESRAGLKLP EFVSKMVEKK WLGNKTKQGF
YKKEVTPDWK KIDKVINYKT LEYETFEKPT FPCLDASKKA ATLPEKMQAI AYGTDKGSIF
MWRTMAEMMI YSANRIPEIA DTIVEIDNAM KWGYAWEMGP FETWDAIGLK RSVDRMKKEG
MKIPKKIQAM IDKKVKSFYK IEKGKKMYYD LKSGKYKVIE TSPLALNLAN LRANKKVVKE
NKSAAIIDLG DGVFNVEFHS KMNAMDGAMG EMIAEGLMYA IDNGVGLVLG NQAPGMPGAF
SAGGDLGYMG DMAKNKNFSG IDTMISDLHK MILALKYAPI PVVAAPYGMT LGGGCEVCLA
SDRIVTHAEL YMGLVEISAG LLPGGCGMMH LWQRYVDAIP GNVKIADWAA YLIPALILVA
QAKVSMSAQE ALKNGFLRAT DKIVFNKDNL IGEAKKEILR MVDDGYAPPA KKKYPVMGQE
AQGMIWADMN NMRIGGYIPK HMEFIAKKII YCMSGGEARQ GQLVSEDYLN KLEREAFVEL
WKTEETQKMA AHIMTTGKPL MM
//
