ID   A0A1G3QDP2_9SPIR        Unreviewed;      1023 AA.
AC   A0A1G3QDP2;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Glutamate synthase subunit alpha {ECO:0000313|EMBL:OHD64550.1};
DE   Flags: Fragment;
GN   ORFNames=A2176_08445 {ECO:0000313|EMBL:OHD64550.1};
OS   Spirochaetes bacterium RBG_13_51_14.
OC   Bacteria; Spirochaetota.
OX   NCBI_TaxID=1802193 {ECO:0000313|EMBL:OHD64550.1, ECO:0000313|Proteomes:UP000176595};
RN   [1] {ECO:0000313|EMBL:OHD64550.1, ECO:0000313|Proteomes:UP000176595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- SIMILARITY: Belongs to the glutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00009716}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OHD64550.1}.
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DR   EMBL; MIBH01000044; OHD64550.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G3QDP2; -.
DR   STRING; 1802193.A2176_08445; -.
DR   Proteomes; UP000176595; Unassembled WGS sequence.
DR   GO; GO:0015930; F:glutamate synthase activity; IEA:InterPro.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:InterPro.
DR   CDD; cd00713; GltS; 1.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR006982; Glu_synth_centr_N.
DR   InterPro; IPR002932; Glu_synthdom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR11938:SF133; GLUTAMATE SYNTHASE (NADH); 1.
DR   Pfam; PF00310; GATase_2; 1.
DR   Pfam; PF04898; Glu_syn_central; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          17..411
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51278"
FT   REGION          894..916
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        902..916
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1023
FT                   /evidence="ECO:0000313|EMBL:OHD64550.1"
SQ   SEQUENCE   1023 AA;  115380 MW;  ACC9430E6F63B547 CRC64;
     MPQRQGLYDS SYEHDSCGIG FVAHIKGAPS YEIIMRGLEV LERMEHRGAE SADNKTGDGA
     GIMMQIPHNL YKDELPSLPE PGHYGTGVVF LPRDVREAEY CIAELERVID EEGMRTLGWR
     PVPVDSSVLG AISRASEPVM KQIFVGERNP QDPSTLERAL FIARKAIENR IRNSSLKEKH
     LFYVPSLSSR TMVYKGMLMP NQVRHYYHDL RDQRTKSAVA LVHSRFSTNT FPSWDLAQPF
     RLLAHNGEIN TIRGNRFWMS ARESSFKSDL FGDNITKILP VIEPDKSDSA SFDNALEMLS
     FTGRSLPHAL MMLIPESWNE KNPIPEELKY FYEYHSTFME PWDGPASMVF CDGRYVGGTL
     DRNGLRPSRY VITHDDLIVM ASEVGVQTFP AEKIAYKGRL MPGKLLLVDM EQGRIIPDEE
     IKRRIYTQKP YRLWVQLNRV NLEDLEIQGD VPVAIDEDRL HEMHLLYGYT REDLEDIITP
     MVETAQEPTG SMGTDTPLAV FSDKPQRLFN YFKQCFAQVT NPAIDPIREE LVMTLTSYIG
     EQKNLLNETP EHCRMIKLKS PIFTNREVEN IRKNEKTESK TITLPMTFPV KTAPGSMKRA
     LDALCVAVED KIDSGYRYII LSDREADKDN APIPSLLACA GVHHHLIRTK KRTLIGLIIE
     TAESREVMHF ALLFGYGASA VNPYGAFATI HSMVNRGELG NTSYLKAEDY FIKAVNKGLL
     KVLSKMGTST LRSYRGSQIF EAIGLGKELI DTCFTGTESR IGGIGFAEAE REALMQHDIA
     YKKRPKLLES PGVYQYRNRG ERHAWNPESI YLLQWATRTG DYGIYKEFSR FMNEQTRTPH
     FIRGLFDFKP QKPISIDEVE PEKNILKRLV TGAMSFGSIS KDAHETIAAA MNRLQGRSNS
     GEGGEDPERF EKRPDGTWTR SAIKQVASGR FGVTSNYLAN ADELQIKIAQ GAKPGEGGQL
     PGHKVDTIIA KTRHSTPGVT LISPPPHHDI YSIEDLAQLI FDLKNANPKA RISVKLVSET
     GVG
//