ID A0A1G3QU67_9SPIR Unreviewed; 455 AA.
AC A0A1G3QU67;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=A2V99_00755 {ECO:0000313|EMBL:OHD70251.1};
OS Spirochaetes bacterium RBG_16_67_19.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802196 {ECO:0000313|EMBL:OHD70251.1, ECO:0000313|Proteomes:UP000177018};
RN [1] {ECO:0000313|EMBL:OHD70251.1, ECO:0000313|Proteomes:UP000177018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR603739-50};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD70251.1}.
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DR EMBL; MIBK01000230; OHD70251.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3QU67; -.
DR STRING; 1802196.A2V99_00755; -.
DR Proteomes; UP000177018; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR003739; Lys_aminomutase/Glu_NH3_mut.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR00238; KamA family radical SAM protein; 1.
DR PANTHER; PTHR30538:SF1; L-LYSINE 2,3-AMINOMUTASE; 1.
DR PANTHER; PTHR30538; LYSINE 2,3-AMINOMUTASE-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01070; PLP-dependent; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR603739-50};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 85..305
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT MOD_RES 310
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR603739-50"
SQ SEQUENCE 455 AA; 50373 MW; A3BD4F8448AF7A15 CRC64;
MTKPRDLPPG LELRPEERAF FRGHRREAPP FAVTRHLLGL LDPADPADPI RRQFLPTASE
LSPGAGELED PLGEDRVQPV PNLLHRYPDR ALLLVTDRCA AYCRHCFRRR VSSGRRRAFL
SPAELEQAAA YVDGHPEIRE LILSGGDPLL LSDARLRALF ARFRRERPEL ALRVHTRLPV
VLPRRVTPAL VRLLAGFRPL RLVVQVNHPR ELDPACRQAL GLLAAAGLPL LAQSVLLAGV
NDRPRTLAEL FAALSGAGVR PYYLFQPDLA RGTAHFRPDP ARGLRLYREA AALGPEAPRY
MLDLPGGGGK VPVEPDLLGE REDGFYLLRR DGVVAARYPC YAGPMSTSGK KPKDFASVMR
KTGKKLGKTL RGAAQATAKA AGKTAEVVAV RTRISAKQVR QKAEFLKMGE SFYRARKSGM
SPEQILASMQ PQVTKLDTLQ QEIATLELRE KTLRN
//
