ID A0A1G3R6L9_9SPIR Unreviewed; 585 AA.
AC A0A1G3R6L9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 28-JUN-2023, entry version 19.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:OHD74099.1};
GN ORFNames=A2V99_09125 {ECO:0000313|EMBL:OHD74099.1};
OS Spirochaetes bacterium RBG_16_67_19.
OC Bacteria; Spirochaetota.
OX NCBI_TaxID=1802196 {ECO:0000313|EMBL:OHD74099.1, ECO:0000313|Proteomes:UP000177018};
RN [1] {ECO:0000313|EMBL:OHD74099.1, ECO:0000313|Proteomes:UP000177018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHD74099.1}.
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DR EMBL; MIBK01000123; OHD74099.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G3R6L9; -.
DR STRING; 1802196.A2V99_09125; -.
DR Proteomes; UP000177018; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR42713; HISTIDINE KINASE-RELATED; 1.
DR PANTHER; PTHR42713:SF2; TWO-COMPONENT SENSOR KINASE YESM; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OHD74099.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 291..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..365
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
SQ SEQUENCE 585 AA; 65482 MW; 632EFD58FC3697C3 CRC64;
MRLRSIRSKL LLSFVAVILL PLLTLGVLGP YLSARTLENE ATSHTWQLIR QVTRNIEFAV
RNTESLIAVV DASPDVQAFL AFAGSAQPFS AQERAAALRL LGSLSDAHPE IAGILVVGED
ARPLGNRIQP ITRDPLTEES WYKQAVANPG TVQLLSRPIG RNLRSSQEYS ADEVVAIVKA
VVDPRSQAVR GVVLIDLRLE VMKQIFADLT VGQGGFLFIQ ERGGAIVYTP VNPVVYRLRD
EWLETPRAIS VRRIQGADYQ IVSQWSEYTQ WKTVGVFPLN EIMAQVSSSR YYSLIIAGVT
VLVALVVSIF FTSGIARPVI ELRSLMKEAE EGNLAVRFEG RQEDEIGYLG KSFNTMIEEV
QKLLDLVYHE QQSKREAELK ILQEQIKPHF LYNTLDTIQW MAQEHGARDI VQVVSALTSL
FRIGLSRGKE MIRLAEELEH VRSYLIIQKA RYEDKFDFSL ASDEEVQSCL VLKLTLQPLV
ENAIYHGIKE RHGHGWIRVE ARRQDGMLLM RVSDDGVGMS PAKLQEVQAL LSVSHPHGDG
LAGYGIHNVH ERIQLSFGSR FGLRFESSQA GTTVEILHPL VSSEE
//
