ID A0A1G4BSQ3_9PEZI Unreviewed; 310 AA.
AC A0A1G4BSQ3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN ORFNames=CORC01_00217 {ECO:0000313|EMBL:OHF04365.1};
OS Colletotrichum orchidophilum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum.
OX NCBI_TaxID=1209926 {ECO:0000313|EMBL:OHF04365.1, ECO:0000313|Proteomes:UP000176998};
RN [1] {ECO:0000313|EMBL:OHF04365.1, ECO:0000313|Proteomes:UP000176998}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMI 309357 {ECO:0000313|EMBL:OHF04365.1,
RC ECO:0000313|Proteomes:UP000176998};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHF04365.1}.
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DR EMBL; MJBS01000002; OHF04365.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4BSQ3; -.
DR STRING; 1209926.A0A1G4BSQ3; -.
DR OrthoDB; 1472480at2759; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000176998; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000176998}.
FT DOMAIN 39..297
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 310 AA; 34503 MW; 24BF787558DF2A4A CRC64;
MAQDPSSTSL VKVPVLLLKT KSTPGDSYED LLSREHDGYA FEPAFVPVLQ HTFQEPGMTT
VQDVLQRRGI NNGIDCSYGG LIFTSQRAVE AFASLVDEKK GTEEKWPHLQ NVPVYSVGPA
TTRALQSISQ EAPLQIFGEH TGNGDALAKY IVSHYGQRYQ DRPTKPPLLF LVGEQRRDII
PKTLMDTKLP SDERIQVDEV VVYGTGVMES FPQDFENHLK ATETRSTRWV VVFSPTGCEG
MLRGLGMLDE STGKAKTDRL DGRKTFIATI GPTTRDYLRR AFDLEPDVCA EEPSPAGVRR
GILHFMGKER
//
