ID   A0A1G4FJ84_9FIRM        Unreviewed;       299 AA.
AC   A0A1G4FJ84;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=General stress protein 69 {ECO:0000313|EMBL:SCL87277.1};
DE            EC=1.1.1.- {ECO:0000313|EMBL:SCL87277.1};
GN   Name=yhdN {ECO:0000313|EMBL:SCL87277.1};
GN   ORFNames=PP176A_1272 {ECO:0000313|EMBL:SCL87277.1};
OS   Sporanaerobacter sp. PP17-6a.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Sporanaerobacteraceae;
OC   Sporanaerobacter.
OX   NCBI_TaxID=1891289 {ECO:0000313|EMBL:SCL87277.1, ECO:0000313|Proteomes:UP000179042};
RN   [1] {ECO:0000313|EMBL:SCL87277.1, ECO:0000313|Proteomes:UP000179042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PP176A {ECO:0000313|EMBL:SCL87277.1};
RA   Seilhamer J.J.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FMIF01000012; SCL87277.1; -; Genomic_DNA.
DR   RefSeq; WP_071139585.1; NZ_FMIF01000012.1.
DR   AlphaFoldDB; A0A1G4FJ84; -.
DR   Proteomes; UP000179042; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd19138; AKR_YeaE; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:SCL87277.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000179042}.
FT   DOMAIN          31..285
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        70
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         128
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            95
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   299 AA;  34043 MW;  272F0C30636CDBCC CRC64;
     MAEIDSERIE NIRNNNLKYR VKLPDGALVP RLGQGTWHLG ENPARRKSEI ETLKFGVELG
     MTLIDTAEMY GNGSSEILVG EAIKGIRDKL FIVSKVYPHN AGLKNIFRSC ENSLKRLNTD
     HLDLYLLHWR GSIPLEETIE GMEKLIKEGK ILRWGVSNFD IDDMKELFKL GNGEHCTTNQ
     VLYHLGSRGI EYDLLSWQEE NHMPIMAYCP MAKAGELRRG LTENSTVRDI AAKYGVKPLQ
     ILLAWCMRSN NVIAIPKSST KEHVLENAQS NFVELTEEDL QQLDTFFPKP HKKVPLDIV
//