ID A0A1G4JE80_9SACH Unreviewed; 876 AA.
AC A0A1G4JE80;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=LADA_0E09274g1_1 {ECO:0000313|EMBL:SCU88285.1};
GN ORFNames=LADA_0E09274G {ECO:0000313|EMBL:SCU88285.1};
OS Lachancea dasiensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1072105 {ECO:0000313|EMBL:SCU88285.1, ECO:0000313|Proteomes:UP000190274};
RN [1] {ECO:0000313|Proteomes:UP000190274}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Devillers H.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; LT598455; SCU88285.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4JE80; -.
DR STRING; 1266660.A0A1G4JE80; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000190274; Chromosome E.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000190274}.
FT DOMAIN 216..358
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 679..830
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 425..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 97799 MW; A6F00EB981BF31FC CRC64;
MSNQIAAINE SDVRRITSGQ VIVDLTSAVK EILDNSIDAG ADQFECVFKN YGMESFECSD
NGSGISEESH AGLALKHHTS KISTFEDVSQ VTTLGFRGEA LSSIAAVANL VVTTTSRAPK
AAKLEFNFKG ELVKSTVTSR NKGTTVHVSQ LFNTLPVRKK EFTRNHKRQF NKCISLLQQY
TIIQDRMKIS VWHITSNGRR TLVLSSTKDQ GIPKRIVGVF GSTAMQGLTE IKLDLAVSSS
KTWASQAFAE EEVEGSPCYN ILVTGYISKN SLGSGRNTKD RQYVYINRRP VVCPSLLKCC
NEVYRTHNNV QFPVCFLNFE VNPSFLDVNV TPDKRTVLLH SENLVIDALR DGLTEFYSQQ
EMVMPVSAAF RTRGTAQEPD LKKPKISAAS QELNFEFSHD EEEMQSTIDV TENTGPKQTI
TATLDRENDV DTDVPSIFVR DPEDSEEVQT GKETSSTAPS QSDHQLSPIS NEERVRTSEN
QVQNQKPIEV FENPSSRKDP SLHVQGLAPS GELLTEGDRV EESAKKTRAN RLIFQTQDAD
SNLNEESCTC SSANEGSLSD DELGASHPNP PFRLARRESN ISMDEMGQIN CTPAPIPLPR
ASLANSAQNS GPGIFATSLA VDPNDLISSF VHETNLIQKQ KVRKHKNYIQ KNEQLDDFDQ
GEKYLTLSVS KADFKTMEIV GQFNLGFILV TRCIGEKFDL FIVDQHASDE KYNFEMLQRT
TVLKSQPLIA PQTVELSVMD ELIAMENLSV LEKNGFKLEV KEDQPQGTRV KLVSLPVSKK
TVFDMNDLHE LLHFVKESDG LNKDAVRCSK VRSMFAMRAC RSSIMVGKPL SKKSMVHVVR
NLSELDKPWN CPHGRPTMRH LLELRDWNAF DEDYAL
//
