ID A0A1G4JGZ9_9SACH Unreviewed; 495 AA.
AC A0A1G4JGZ9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Class E vacuolar protein-sorting machinery protein HSE1 {ECO:0000256|ARBA:ARBA00017923};
DE AltName: Full=Class E vacuolar protein-sorting machinery protein hse1 {ECO:0000256|ARBA:ARBA00018978};
GN ORFNames=LANO_0D05820G {ECO:0000313|EMBL:SCU89642.1};
OS Lachancea nothofagi CBS 11611.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1266666 {ECO:0000313|EMBL:SCU89642.1};
RN [1] {ECO:0000313|EMBL:SCU89642.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR EMBL; LT598448; SCU89642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4JGZ9; -.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000189911; Chromosome d.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd16978; VHS_HSE1; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF3; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 14..139
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 217..276
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 181..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 342..369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 421..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55384 MW; B57970BD8AD7E282 CRC64;
MVSESLLRTA VFKATDGKLR ADNWQYIIDV CDVVKEDPED GGRLVIDIVE ERLKETDANV
ILRTLSLVVS LAENCGSRLQ QAVSSKKFTK VLMGLIKSTG VHWLVKKEVA KTVAQLSDSF
KKDPSLKPMQ DLFSDIRAKE PGLLEEQAVP RKTEMSNETK RSEDKELEEA LRLSIMEYTK
TGGSQHSLES QNKAHVSHAE ERGSSTSPGN GQAPSPAVVR KVRALHDLSG RDSEELSFRK
GDVITVIEQV YRDWWRGSLR GNVGIFPLNY VTPVAEKTVQ EMDHERAQED AMLAQISRVD
KLHQTMRNAG HNFEITQDQE VTDLYSSITP LRPQLTKMIG NCAQKKEEYS SLRRVLADAE
ASYNQLLNRA SHSYALPSIQ QARPDYMRGA RQPSYTGPLG NHQPQSANSY VHAQPYLTGE
GAPDYNQQMQ QQQHSIGSPQ HPQQRQPSQQ HQLQYQGLQQ GLLQGSQQGP SAGNNNSTYP
TPYPISNQNT GLRKD
//
