ID A0A1G4JND3_9SACH Unreviewed; 663 AA.
AC A0A1G4JND3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=LAMI_0E09230G {ECO:0000313|EMBL:SCU92198.1};
OS Lachancea mirantina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1230905 {ECO:0000313|EMBL:SCU92198.1, ECO:0000313|Proteomes:UP000191024};
RN [1] {ECO:0000313|EMBL:SCU92198.1, ECO:0000313|Proteomes:UP000191024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 11717 {ECO:0000313|EMBL:SCU92198.1};
RA Devillers H.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; LT598465; SCU92198.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4JND3; -.
DR STRING; 1230905.A0A1G4JND3; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000191024; Chromosome e.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000191024}.
FT DOMAIN 18..262
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 367..600
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 83..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 74709 MW; 792B6AE2CDE06040 CRC64;
MSTESDIARK FGEGAENPEI LRLLKDIESI YSLDTEELYI KWEQFSYHKN GKVAELNLRN
VELFKGFIQQ QIERKAATIG LNNSGSASVR RPKIAKPSNG GSPSLFGFAS PKTPLMKKRR
TDTTPSKLGN LHMKSDISAD DTLGSIERSR YDLESPSGTS RSAEVSSPFM VSNVENKTEK
GQILLTLNPQ NIEMSKGQKF ETKNKVSIVP FFDSEKYQYR TMRQNILEAA DVLDEQIDIF
TEAVQQHYNL AVSDIGDPSR QSQSEIIAVG RIVADAADSE SNVNIHSLAI EASRSMGIGR
RVRLNLEKIE EASFFQGQIV ALRGKNANGE YFMVEEVMDI PFLNSPVSTL KELKEFEEEP
EEESLKIVIT KGPYTAANEL DFSFLKEFVE RLNTELVPHV LMMFGPFLDI MHSQIESGCI
PHFPGLTTQP RTLDEIFNKV VSPILKNINE KIQVILIPST NDAIMKHASY PQCAMDRKAL
HLPKTFKCFP NPSIFKLNEF FFGCSNLDAF KDIREAVKGG KTYSRNRLDR IAEHVLQQRR
FYPSFPGSIK KRKTVNAKGQ EVWEHLSGAN LEVDFLGLSE FVAKLIPDVV LIPSELTYFA
RIVRNVLFVN PGPFVRPTGL RGSFAQVCVQ SPEKSGVELT RVDGEEVLYT NDIWKRSRVD
IIT
//
