ID   A0A1G4K8D5_9SACH        Unreviewed;       983 AA.
AC   A0A1G4K8D5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=LAMI_0G04016g1_1 {ECO:0000313|EMBL:SCV00280.1};
GN   ORFNames=LAMI_0G04016G {ECO:0000313|EMBL:SCV00280.1};
OS   Lachancea mirantina.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=1230905 {ECO:0000313|EMBL:SCV00280.1, ECO:0000313|Proteomes:UP000191024};
RN   [1] {ECO:0000313|EMBL:SCV00280.1, ECO:0000313|Proteomes:UP000191024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 11717 {ECO:0000313|EMBL:SCV00280.1};
RA   Devillers H.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LT598469; SCV00280.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G4K8D5; -.
DR   STRING; 1230905.A0A1G4K8D5; -.
DR   OrthoDB; 170190at2759; -.
DR   Proteomes; UP000191024; Chromosome g.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191024};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          51..205
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          59..91
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          73..101
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          119..149
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ   SEQUENCE   983 AA;  110512 MW;  73F91121245D7179 CRC64;
     MASENEHFTS QTVDSKINGN DVHNEEFYTY SDDDLIEDFT QEHEELGNTA IRTESEYACA
     YCGIDSPKCV AKCNTCNKWF CNSRNGTSSS HIINHLVLSH HNVVSLHPES DLGDTVLECY
     NCGCKNAFVL GFVSAKTEAV VVLLCRLPCA QTKNINWDTD QWQSLIENRQ FLSWVAEEPG
     EDELLKARII TPAQISKLEA KWRSNKDATI NDIESQDEQE QVTHVLMRYT DAYQYQRSFG
     PLVKLEADYD KQLKESQALE HISVSWSLGM NKRHLASFAL STFESNGLKV AVGDEMILRY
     SGLQFPEWEG RGYIVPLPNS FQDEFTLELK ASKNAPPTNM TTGFTAEFVW KGTSYDRMQE
     AMKKFAVVKK SISGFLYYKI LGHEVPDLEF DVNLPEQFSI PHFAQLNVSQ ANAVRHVLQR
     PLSLIQGPPG TGKTVTSATI VYHLSRLHKE RILVCAPSNV AVDHLASKLR DLGLKVVRLT
     AKSREDVESS VSDLGLHNLV SRSAKGELKK LLKIKEESGE LSSIETKKFV KQVKKSEVEI
     LKKADVVCCT CVGAGDRRLE AKFRTVLIDE STQASEPECL IPIVKGAKQV ILVGDHQQLG
     PVILDRKAAD AGLRQSLFER LISLGHTPIR LEVQYRMNPH LSEFPSNMFY EGSLQNGVTI
     EQRTIAKSTF PWPIHDVPMM FWSNYGREEI SGNGTSYLNR IEAMNCERVI TRLFRDGVNP
     EQIGVITPYE GQRAYIVQYM QMNGSLDKEL YMNVEVASVD AFQGREKDYI ILSCVRANEQ
     QAIGFLSDPR RLNVALTRAK YGLVILGNPK SLSRNSLWSH LLIHFREQGC LVEGSLDNLQ
     LCTVQLTKTR TTPNERRMIS QRLDLSQAGS FNQMGFDDVD TQSLISFGGP ENFGSNGFEA
     LHKEQDTKIV NSSIWQAEAF QQRFGGKEQP GANVYSEKFG LDSSLARGLQ NNNGAFSKYD
     YKGPDGDDRM KGLHSFRELN ISG
//