ID A0A1G4KBV4_9SACH Unreviewed; 600 AA.
AC A0A1G4KBV4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=LAMI_0G14026g1_1 {ECO:0000313|EMBL:SCV01833.1};
GN ORFNames=LAMI_0G14026G {ECO:0000313|EMBL:SCV01833.1};
OS Lachancea mirantina.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1230905 {ECO:0000313|EMBL:SCV01833.1, ECO:0000313|Proteomes:UP000191024};
RN [1] {ECO:0000313|EMBL:SCV01833.1, ECO:0000313|Proteomes:UP000191024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 11717 {ECO:0000313|EMBL:SCV01833.1};
RA Devillers H.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
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DR EMBL; LT598469; SCV01833.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4KBV4; -.
DR STRING; 1230905.A0A1G4KBV4; -.
DR OrthoDB; 52228at2759; -.
DR Proteomes; UP000191024; Chromosome g.
DR GO; GO:0030697; F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR030391; MeTrfase_TrmA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR025795; tRNA_(uracil-5-)_MeTrfase.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR NCBIfam; TIGR00479; rumA; 1.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS51622; SAM_MT_RNA_M5U_2; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
DR PROSITE; PS01231; TRMA_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024}; Reference proteome {ECO:0000313|Proteomes:UP000191024};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT DOMAIN 128..194
FT /note="TRAM"
FT /evidence="ECO:0000259|PROSITE:PS50926"
FT ACT_SITE 552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 552
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 423
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 457
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 478
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 525
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 600 AA; 66987 MW; 21525D8799A6CCF2 CRC64;
MLISFKVLHT IALKIPPFKA ACRPRFFCRL KPIPTSFRFV SEAMSVEQRS DSKRGGVDEE
PQRKPIKIAK KTKLKKYKAK KVDPTAPLGV LQGEIDELLL EFDKTREQVT NDVTAILNDT
HSQTGPIASL YHRLVPDVKV IKLTASGDAL AFIQNPVETD KNQVALIPFA FPGDVVDIKV
FKTHPHYVEC DLLEIKEPSK SRNNELIRCQ YFGKCSGCQF QPFSYEEQLQ IKRATVENAY
KYFAPNLMQE GLIPVVGNTV GSPLTYGYRT KLTPHFDIPR KLDKLNKRPP LGFGQKGRPT
WRNTNAGGDA SILDVEECVI GTSIINQGMK NERAEFDKTY KDFKRGATIL LREHTKILDE
NESVESQLDK GSLNPENGAV SYQVSDGAAG TKLLKTCVTD SRQVVTENID GYTFNFSAGE
FFQNNNSILP LVTSYVRDNL QIPTSATTEP HYLVDAYCGS GLFSITASKG VDKVIGVEVS
ADSVRFAEKN ALANGVKNCT FVVGKAEKIF ASIDTPSDRT SVILDPPRKG CDEVFLKQLA
DYYPARIVYV SCNVHSQARD VAFFLKNTTR GKDYKIESLR GFDFFPQTHH VEGVCVLSRY
//