ID A0A1G4KLI9_9SACH Unreviewed; 694 AA.
AC A0A1G4KLI9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=Diphthine--ammonia ligase {ECO:0000256|ARBA:ARBA00018426};
DE EC=6.3.1.14 {ECO:0000256|ARBA:ARBA00012089};
DE AltName: Full=Diphthamide synthase {ECO:0000256|ARBA:ARBA00029814};
DE AltName: Full=Diphthamide synthetase {ECO:0000256|ARBA:ARBA00031552};
GN ORFNames=LANO_0H05336G {ECO:0000313|EMBL:SCV05340.1};
OS Lachancea nothofagi CBS 11611.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1266666 {ECO:0000313|EMBL:SCV05340.1};
RN [1] {ECO:0000313|EMBL:SCV05340.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + diphthine-[translation elongation factor 2] + NH4(+) =
CC AMP + diphosphate + diphthamide-[translation elongation factor 2] +
CC H(+); Xref=Rhea:RHEA:19753, Rhea:RHEA-COMP:10172, Rhea:RHEA-
CC COMP:10174, ChEBI:CHEBI:15378, ChEBI:CHEBI:16692, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:82696,
CC ChEBI:CHEBI:456215; EC=6.3.1.14;
CC Evidence={ECO:0000256|ARBA:ARBA00001559};
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DR EMBL; LT598447; SCV05340.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4KLI9; -.
DR OrthoDB; 103959at2759; -.
DR Proteomes; UP000189911; Chromosome h.
DR GO; GO:0017178; F:diphthine-ammonia ligase activity; IEA:UniProtKB-EC.
DR CDD; cd01994; Alpha_ANH_like_IV; 1.
DR CDD; cd06155; eu_AANH_C_1; 1.
DR CDD; cd06156; eu_AANH_C_2; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.1490.10; putative n-type atp pyrophosphatase, domain 2; 1.
DR Gene3D; 3.30.1330.40; RutC-like; 2.
DR InterPro; IPR002761; Diphthami_syn_dom.
DR InterPro; IPR030662; DPH6/MJ0570.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR035959; RutC-like_sf.
DR InterPro; IPR006175; YjgF/YER057c/UK114.
DR NCBIfam; TIGR00290; MJ0570_dom; 1.
DR PANTHER; PTHR12196:SF2; DIPHTHINE--AMMONIA LIGASE; 1.
DR PANTHER; PTHR12196; DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN; 1.
DR Pfam; PF01902; Diphthami_syn_2; 1.
DR Pfam; PF01042; Ribonuc_L-PSP; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55298; YjgF-like; 2.
PE 4: Predicted;
FT DOMAIN 1..226
FT /note="Diphthamide synthase"
FT /evidence="ECO:0000259|Pfam:PF01902"
SQ SEQUENCE 694 AA; 78003 MW; 663B8483BCF6AFC6 CRC64;
MKFIALVSGG KDSCYSILHS IRQGHEIVAL GNLHPVDESQ QELDSYMFQT VGHDIVKWYQ
KCTGLPLIRR AIRPATSKNV SLNYFPTEED EIEDLLELLK EAKRLIPDLA AVNAGAILSS
YQRTRVEDVC SRLGLVSLSY LWQRNQKQLM TEMCYMSKLD CEEHAQKMDA RLIKTAAVGL
DQQVLGKSLP QIFPLLLKLN ERYDVHICGE GGEFETMVFD APIFHHGYLR AHVLETEGSD
NSDGVYSARM EVEFVERENS QTLSNLLKDL PVPKVLEDPW MELLEQVTIA VDDPNDIEYP
YKEEIPHSSN TSINEIKNLM YVSNITPKNG DTVETKTRDV FAQLNEILKK RSLFPSQILA
SSLLLEKMSN FASVNAVYND FFQVTNNGPL PPSRSCVGSS LVGRNKTLQL SVIVDTEGKI
REQKNMVFNE TKGGLHVQGR SYWAPCNIGP YSQAIWNKDD ANQISYISGQ IGLIPATMIM
TGALDEKTND NVSQAVLSLR HFDTIKIAIN AQHQLTTVCY VSEEFMVPIV AKVWALYCKE
MAASVDSWFE RPTEDPRSLI IVKISELPRE AKCEWGGVAC SRLTAESDDC YESDSDGNAC
DISKTSNAPH LPEGFSVSVQ NSKKCRTYYT GFLDSQKELE RFIETRTISQ ATIFYQPTFG
LPVNISQNGI ELFPVEKVYD HNGCEKLVGI QMVC
//