ID A0A1G4KNN9_9SACH Unreviewed; 1455 AA.
AC A0A1G4KNN9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Transcription elongation factor Spt6 {ECO:0000256|ARBA:ARBA00020248, ECO:0000256|PIRNR:PIRNR036947};
GN ORFNames=LANO_0H20494G {ECO:0000313|EMBL:SCV06027.1};
OS Lachancea nothofagi CBS 11611.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=1266666 {ECO:0000313|EMBL:SCV06027.1};
RN [1] {ECO:0000313|EMBL:SCV06027.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression. {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR EMBL; LT598447; SCV06027.1; -; Genomic_DNA.
DR OrthoDB; 170310at2759; -.
DR Proteomes; UP000189911; Chromosome h.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 2.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}.
FT DOMAIN 1244..1341
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 167569 MW; 6784AFE763FB0D5A CRC64;
MSSEAVKPTE DPVVDDNIEG GKAPSDEEEG EDVFDSSEED EDLDEDEEEA KKVREGFIVD
DDEEGRAAVG RRRSKKHKRR AREDEDDKLS EDDLDLLMEN AGVKRPTSPD SNKVKLKRLK
RAGDNGEEEP SDTTSKAATA TSRFDDFFSD DEDEQPEGGL PPTGGEGVAP GARNAELGTI
DELDDFIEED EFSDEDEESR QQRLQERKML REQRMNQPVQ ITGLSSEKID EMYDIFGDGH
DYDWALEVEN EDLEQAETGE GADGTDDFDA EGLNGEIKKP KITLQDIYDL QDLKKNLMTE
EDMVIRRSDV PERYQELRVG LKNYGQLSAE DQELEKNWIS DRLCVDKNFE PEYDLTEFKE
AVGNAIRFVS KDNLEVPFIY AYRRNYISSK EKDGFVLNED DLWEIVYMDS EFHSIIYKRD
YVKKFYEQLG LRDAIVDEYF KSEASPMTEL NSLQDIYNYL EFKFAHEINE ALLSQNNGST
KKHLKNSSYE KFKSSSLYKA VKDIGITSDE VGENIHSEHQ IHPVVDHPEL KPKDVIENLL
AESGADLQIF SSNHKLALET VQKYYSLEIA NNPKVREKVR TDFYKYYIAD VVLSIKGKKE
IQRGSPYEDI KYAINRTPAN FRKEPEVFLR MLEAESLHLM TIKIYMSSQA QYCDHLFQTA
LDTTNTSEIA TEWNNFRRTA FFAALDKIFL EISQEIKDDL RKTCQKLVSK SVRHKFMTKL
DQAPYIPNPR DPKIPRVLAI TCGEGRFGAD AIIAVYVNRK SDYVRDYKIV DNPFDRNNPE
KFEETLDNII QACQPNAIGI NGPNPKTQRL ARKIQEVIQK KQIVDNRGHN IPVIYVEDEL
ATRYQTSERG IQEFPNKPSL VKYCIALARY MHSPLLEYVN LSPDELMSLS IHPNQSLLTR
DNFMKALETS FVDLVNLVGI EVNKATDNGY YARCLQYISG LGKRKATDFL ESLQRLNEPL
LARQQLITHN ILHKTIFMNS AGFLYISWNQ KNQRYEDLEH DQLDSTRIHP EDYHLATKVA
ADALEYDPDA IAEKEEQGSM SEFIEILRED PDCKTKLESL NLEAYAEELE KNSGQKKLNN
LNTIVLELLN GFEELRNDFH PLNAEEVFTA LTGESDKTFF KGCIVPVKVE RFRHSDIICA
TNSLVECIVN SQRHLGAQLK RQASELYEIG MTYPAKVIFI DYENISAEIS FLEHDVKHQY
VPVHYSKDPS IWDLKQELED SEEEKQIAMR EARAKRTHRV INHPYYFPFN GAQAEDYLRS
KERGDFVIRQ SSQGDDHLSI TWKLDKDLFQ HVDIVEQEKE NPLALGRVLL VEGQVYHDLD
QIVVEYLQNK VRLLNEITSN EKFKKGTKRE VTKFIEDYSK VNPNRSVYYF SFNYEHPGWF
YLMFKINAQS KLYTWNVRLA HTGFVLVNYN YPTVIQLCNG FKTLLKTSNR NQRPGTAAGS
APAATAGAAG GYYGY
//
