ID A0A1G4MC71_LACFM Unreviewed; 494 AA.
AC A0A1G4MC71;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=LAFE_0E00716G {ECO:0000313|EMBL:SCW01487.1};
OS Lachancea fermentati (Zygosaccharomyces fermentati).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=4955 {ECO:0000313|EMBL:SCW01487.1, ECO:0000313|Proteomes:UP000190831};
RN [1] {ECO:0000313|Proteomes:UP000190831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Devillers H.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; LT598488; SCW01487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4MC71; -.
DR STRING; 4955.A0A1G4MC71; -.
DR OMA; AKWRAQT; -.
DR OrthoDB; 1341425at2759; -.
DR Proteomes; UP000190831; Chromosome e.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000190831}.
FT DOMAIN 41..372
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 438..490
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 494 AA; 53500 MW; 658364FA1BEE99B4 CRC64;
MLKITANSAN KRLASSSTQR LMSSSSALAQ QKFRIETDAF GEIKVPADKY WGAQTQRSFQ
NFKIGGARER MPEPVIKAFG ILKKSAAIVN ESLGTLDPKI SKPIQEAADE VIQGKLMDHF
PLVVFQTGSG TQSNMNANEV ISNRAIELIG GKMGSKTIHP NNHCNQAQSS NDTFPSVMHI
AAVTEITHSL IPELTALRDS LAKKSEEFKD IVKIGRTHLQ DATPLTLGQE FSGYVQQLTN
GLYRVEQTLY HLKFLAQGGT AVGTGLNTKV GFAEKIAAQV SKETGIDFRT APNKFEALAA
HDAVVECSGA LNTLACSLFK IANDIRYLGS GPRCGYGELS LPENEPGSSI MPGKVNPTQN
EAMTQVCVQV MGNNAAISFA GASGQFELNV FKPVMISNLL SSIRLLSDAC YSFRVHCVDG
IEANKDKINK LLHESLMLVT ALNPKIGYDA ASKVAKNAHK KGITLKESAL ELKVLTAEEF
DQWVVPENMI GPKE
//
