ID A0A1G4MEH7_LACFM Unreviewed; 547 AA.
AC A0A1G4MEH7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=LAFE_0F04082G {ECO:0000313|EMBL:SCW02331.1};
OS Lachancea fermentati (Zygosaccharomyces fermentati).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=4955 {ECO:0000313|EMBL:SCW02331.1, ECO:0000313|Proteomes:UP000190831};
RN [1] {ECO:0000313|Proteomes:UP000190831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Devillers H.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
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DR EMBL; LT598490; SCW02331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4MEH7; -.
DR STRING; 4955.A0A1G4MEH7; -.
DR OMA; FYLGTME; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000190831; Chromosome f.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000190831};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 131..212
FT /note="PX"
FT /evidence="ECO:0000259|Pfam:PF00787"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61905 MW; 7D1B9C4528EFF8FC CRC64;
MTSAIPYDPY DDIDNNPFSE PQPTSVAPEA ESAVATEAQD VHEGPLTQPS EQPDLQPSQE
GHVANQNSNS TTTDQAGPQS EQDDSLLPER KLNKYKLVVK VTGLERAGSV TNKKENPTII
FDVSTNLPTF RKPQHRNLRK TLDEFQNLFK FLNGAIPETF IPAIPPPRTS YGISNQEDYQ
RTVSNFQMWF DRLCADPLIL RNEEIAFFME SDLNTYTPVG KVKLPAAGLK RKTLKQLAPP
YDECIELAEF RPLVKSIHHQ CQEIQLKLFK LCKLKKTLSA DENGVGKGFA EIPIDVAQKH
GKMYKRFGKT LTAVGDIDSV IATLDMATLH DGLEWIVQDT YVVKEAMTNR HFLMRDLLQA
QQNSKFRQEQ ARKLRAKRDV SPLKVDEAIR QLKYATTVEH ELTMKLKRTT ANMLLEKQRW
LDWYSAFLST SVKEYTLRKI EYERKKLSLL ERIRADVRSA DENGGLSRLG RSRSTTSSDL
HPSQTAHGDS WAGDARRRSQ AFESDVLHTE FDDALCRDEA PASTLNPEDQ HALDARNAAT
LLGQSTF
//
