ID A0A1G4V936_9FIRM Unreviewed; 739 AA.
AC A0A1G4V936;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=SAMN02910339_00512 {ECO:0000313|EMBL:SCX03152.1};
OS Lachnospiraceae bacterium YSD2013.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1520828 {ECO:0000313|EMBL:SCX03152.1, ECO:0000313|Proteomes:UP000199278};
RN [1] {ECO:0000313|EMBL:SCX03152.1, ECO:0000313|Proteomes:UP000199278}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YSD2013 {ECO:0000313|EMBL:SCX03152.1,
RC ECO:0000313|Proteomes:UP000199278};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; FMTX01000007; SCX03152.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4V936; -.
DR STRING; 1520828.SAMN02910339_00512; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000199278; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000199278}.
FT DOMAIN 331..518
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 342..346
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 739 AA; 82185 MW; A03907266805A8AA CRC64;
METIQGFISS IRYRNPDNGY SVLSFVVDDN EETLVGNFLS VSEGEMLKVT GEWVVHPIYD
KQFKATSYES IQPEDELAVL RYLSSGIIKG IGPTLAKRIV DEFGKDTFMV MEEQPELLER
VKGITLKKAQ EIGVLMQEKR GYREAMMFLT KYGIGNALAI KVYSYYGDRI YSILKENPYK
LAEDIPGIGF KTADEIAARL GVKGDSNYRI QSGILYTLVL ATGQGHMYLP KDILEEEASK
ILDVTADLVQ PEIDNLTVER KLIIKGTDVY APSNFYVEQS VAGLLRSVVS DVFCDEYEDD
LSIAKEVENI ATQAGYALDP LQTKAVVQAI TNGVSIITGG PGTGKTTTIK TLIGYFDAEG
MDIALAAPTG RAAKRMTEAT GYEAKTIHRL LELNGTIDED GKDAGFERNE DNPLDVDAVI
VDEMSMVDIF LFRALLKAIP PGARLVMVGD AHQLPSVGPG QVLRDLLESE CFPVTRLETI
FRQEGSGDIV VNAHRINNGE DIETPKGSRD FFFIERSDPS KIMLNMVELI TKNLPGYVGA
EPFDIQVLTP TRKGNLGVIT LNRYLQNALN PPSKDKAEHY YGEEIFREGD KVMQIRNNYQ
ANWEVLGKHN IPIDSGIGIF NGDMGRIVEI DESDSSLTVE FDDNKRVTYD FTNLDELELA
YAITVHKSQG SEYGAVIMPV APGPRQLMNR NLLYTGVTRA KKCLVMIGNP GIVHEMIENN
HENLRYSGLK CRIIEMFTE
//
