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Database: UniProt
Entry: A0A1G4VGP1_9FIRM
LinkDB: A0A1G4VGP1_9FIRM
Original site: A0A1G4VGP1_9FIRM 
ID   A0A1G4VGP1_9FIRM        Unreviewed;       404 AA.
AC   A0A1G4VGP1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-JUN-2019, entry version 6.
DE   RecName: Full=Transcription termination/antitermination protein NusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   Name=nusA {ECO:0000256|HAMAP-Rule:MF_00945};
GN   ORFNames=SAMN02910436_00468 {ECO:0000313|EMBL:SCX05727.1};
OS   Ruminococcaceae bacterium P7.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   unclassified Ruminococcaceae.
OX   NCBI_TaxID=1200751 {ECO:0000313|EMBL:SCX05727.1, ECO:0000313|Proteomes:UP000199540};
RN   [1] {ECO:0000313|EMBL:SCX05727.1, ECO:0000313|Proteomes:UP000199540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P7 {ECO:0000313|EMBL:SCX05727.1,
RC   ECO:0000313|Proteomes:UP000199540};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in both transcription termination and
CC       antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-
CC       dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945}.
CC   -!- SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00945}.
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DR   EMBL; FMUA01000003; SCX05727.1; -; Genomic_DNA.
DR   Proteomes; UP000199540; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-UniRule.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1480.10; -; 1.
DR   Gene3D; 3.30.300.20; -; 2.
DR   HAMAP; MF_00945_B; NusA_B; 1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR025249; KH_dom_NusA-like.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR030842; NusA_bac.
DR   InterPro; IPR036555; NusA_N_sf.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR013735; TF_NusA_N.
DR   InterPro; IPR010213; Tscrpt_termination_fac_NusA.
DR   PANTHER; PTHR22648; PTHR22648; 1.
DR   Pfam; PF13184; KH_5; 1.
DR   Pfam; PF08529; NusA_N; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00322; KH; 2.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54814; SSF54814; 2.
DR   SUPFAM; SSF69705; SSF69705; 1.
DR   TIGRFAMs; TIGR01953; NusA; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199540};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199540};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription antitermination {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00945};
KW   Transcription termination {ECO:0000256|HAMAP-Rule:MF_00945}.
FT   DOMAIN      138    204       S1 motif. {ECO:0000259|PROSITE:PS50126}.
FT   REGION      347    376       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1G4VGP1}.
FT   REGION      385    404       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1G4VGP1}.
FT   COMPBIAS    349    376       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A1G4VGP1}.
SQ   SEQUENCE   404 AA;  44615 MW;  4FE0535935B218DD CRC64;
     MTNKELFEAL RMFEKEKDIP MEYMLAQIEK AIKVACKNYF DGNEDVTFTA DPDKNTIDVK
     LKKTVVDEVF DPSFEISLED AQKALKRKTI ELGDEVDVPL DPKKLGRIAI SSARNVIRQG
     IRASEKGQTL IEFQNRLGEI ATATVERIDP RSGSATIRIG KSEAMLPKSE QLGLENIKEG
     DHVKVYIADV KDNEKGPHAI ISRTHSDFVR RLFEKEVPEI FDGIVEIKSV SREAGSRTKM
     AVTSANPDID AIGACIGQRG ARVNSIVAEL GGEKIDIIEY SDDPKKYISA ALSPAQVIKV
     EITDEEKRSC RATVPDGQLS LAIGNKGQNA RLAARLTGWR IDIRPESGFY GEDEEEEKPA
     ETAENAEAEE IVEAPETEEI AAAEETEELF ETEETEAADG AEEG
//
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