ID A0A1G4W6R5_9FIRM Unreviewed; 517 AA.
AC A0A1G4W6R5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Metal binding domain of Ada {ECO:0000313|EMBL:SCX17618.1};
GN ORFNames=SAMN02910339_02456 {ECO:0000313|EMBL:SCX17618.1};
OS Lachnospiraceae bacterium YSD2013.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1520828 {ECO:0000313|EMBL:SCX17618.1, ECO:0000313|Proteomes:UP000199278};
RN [1] {ECO:0000313|EMBL:SCX17618.1, ECO:0000313|Proteomes:UP000199278}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YSD2013 {ECO:0000313|EMBL:SCX17618.1,
RC ECO:0000313|Proteomes:UP000199278};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FMTX01000024; SCX17618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4W6R5; -.
DR STRING; 1520828.SAMN02910339_02456; -.
DR OrthoDB; 9783680at2; -.
DR Proteomes; UP000199278; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035451; Ada-like_dom_sf.
DR InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF02805; Ada_Zn_binding; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199278};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..329
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 396..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 56948 MW; 03B249F0609CC52D CRC64;
MIKNVIKWAF AASFALMSLV CILMGTKVSA LLWLIIAFGV SPLFSELMSR LNIHIRLKTY
AIGLISCILV ATFAIGIEYS ESEDETIPKS VETVSVEERV IDSDVPAVEE VADEVEKDEI
LLEEESLELN VHFIDVGQGD CTLLESKGKY MLIDAGPDNV GTKIQKYLSD VGVTKLDYFI
LTHPDSDHIG SADVVATKFD IDTIYMSSFI KDNKYYHDML DAFAYKNLKW SIPEEDTAFE
LGDATVTILH TKEYDDPNNS SLCVKVTCGD TAFLFAGDAE ATAEKDMIAQ NKDLSATVYH
VSHHGSYTSS TKEFLDLINP KYAVVSCAKD NEYGHPHQET LDTLREKNVA LFRTDLQGGI
TAFSDGKEIQ WSTIPEKEYK GGDSALEKKA KSQEFYTLDN ETQGDSTNVT KSVPSDNTDN
TKASESTGKQ ESKSSNGGSS NSNGGNGGSN LKGFQNDPVP SEAVYIGNKN NMKLHCADCK
GNLPKEKNRV YFNSLEEAEA AGYTKEKQCH NCYPYGK
//
