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Database: UniProt
Entry: A0A1G4WEX2_9MYCO
LinkDB: A0A1G4WEX2_9MYCO
Original site: A0A1G4WEX2_9MYCO 
ID   A0A1G4WEX2_9MYCO        Unreviewed;       525 AA.
AC   A0A1G4WEX2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   SubName: Full=HAMP domain-containing protein {ECO:0000313|EMBL:SCX21645.1};
GN   ORFNames=SAMN02799620_03047 {ECO:0000313|EMBL:SCX21645.1};
OS   Mycobacterium sp. UNC267MFSha1.1M11.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1502745 {ECO:0000313|EMBL:SCX21645.1, ECO:0000313|Proteomes:UP000199707};
RN   [1] {ECO:0000313|EMBL:SCX21645.1, ECO:0000313|Proteomes:UP000199707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UNC267MFSha1.1M11 {ECO:0000313|EMBL:SCX21645.1,
RC   ECO:0000313|Proteomes:UP000199707};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; FMUB01000006; SCX21645.1; -; Genomic_DNA.
DR   Proteomes; UP000199707; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199707};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     31       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    186    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      207    259       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      288    508       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED      258    285       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   525 AA;  57227 MW;  070A8A1430E57A1D CRC64;
     MRLTVQGWQN LVLSVMGVVV LSGAVGGALL MSRTDQVSGE LIDHIQPARV AAYELQAALR
     DQETAVRGYA IAADAQFLTP YQEGQRNEGA SAQVIRDLLA GRDEFVGDLD AIERAAREWR
     AGYAEPLIAS VTPGRPVVVD SGTAERGKDE FDGLRTLFDV QNAHLGQARN AAIDELNWVR
     HWRDGVLVAM VLAFFVMAVL LAVVVRNAVT RPLGLLAASC RRITEGNFGE RIIPQGPSDI
     RAIAAGVEDM RQRIVEELAV SQAARDSLDE QAEELRRSNA ELEQFAYVAS HDLQEPLRKV
     ASFCQLLEKR YGDKLDERGT EYIAFAVDGA KRMQVLINDL LTFSRVGRLN ATHTEVDLDA
     ALDSALKNLA AAIDESGAQV IRPPEPLPLV DGDPTLLAML WQNLIGNAIK FRREGVAPGV
     DVECREGSGE TAGYWVFTVS DNGIGIGVEF VDKVFVIFQR LHGRDAYSGT GIGLALCKKI
     VEHHGGLIWI DTSYTGGSRF VFTLPITPAT EPNPIPEVVS EGHRE
//
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