ID A0A1G4WGR5_9MYCO Unreviewed; 262 AA.
AC A0A1G4WGR5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase MabA {ECO:0000256|ARBA:ARBA00040781};
DE AltName: Full=3-ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00033040};
DE AltName: Full=Beta-Ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00029743, ECO:0000256|ARBA:ARBA00032683};
GN ORFNames=HZU40_07190 {ECO:0000313|EMBL:QNJ94066.1}, SAMN02799620_03135
GN {ECO:0000313|EMBL:SCX21948.1};
OS Mycolicibacterium fluoranthenivorans.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=258505 {ECO:0000313|EMBL:SCX21948.1, ECO:0000313|Proteomes:UP000199707};
RN [1] {ECO:0000313|Proteomes:UP000199707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC267MFSha1.1M11 {ECO:0000313|Proteomes:UP000199707};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SCX21948.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC267MFSha1.1M11 {ECO:0000313|EMBL:SCX21948.1};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QNJ94066.1, ECO:0000313|Proteomes:UP000515498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2A {ECO:0000313|EMBL:QNJ94066.1,
RC ECO:0000313|Proteomes:UP000515498};
RA Chen W., Faulkner N., Smith C., Hyman M.;
RT "Draft genome sequence of four isobutane-metabolizing strains capable of
RT cometabolically degrading diverse ether contaminants.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+)
CC + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA-
CC COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100;
CC Evidence={ECO:0000256|ARBA:ARBA00023333};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17399;
CC Evidence={ECO:0000256|ARBA:ARBA00023333};
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; CP059894; QNJ94066.1; -; Genomic_DNA.
DR EMBL; FMUB01000006; SCX21948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4WGR5; -.
DR STRING; 1502745.SAMN02799620_03135; -.
DR Proteomes; UP000199707; Unassembled WGS sequence.
DR Proteomes; UP000515498; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42879; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE; 1.
DR PANTHER; PTHR42879:SF2; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG; 1.
DR Pfam; PF13561; adh_short_C2; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}.
SQ SEQUENCE 262 AA; 27553 MW; AE7DD346A422C26B CRC64;
MNIDLSGKTA LVTGSTQGIG LAIAEGLARS GARVAVNGRT AARVDEAAER VRGLGGTAFG
VAADVSTEEG TAQLLAQLPE VDILVNNLGI FGAVPAREIT DAQWRTYFEV NVLAAVRLIR
AYLPGMADRG WGRAIQIASD SAIVIPEEMI HYGVSKTALL AVSRGFAKDA AGTGVTVNSV
IAGPTHTAGV EDFVYELVDK SLPWEEAQRE FMVKYRPQSL LQRLIEPAEI ANMVTYLASP
LASATTGGAL RVDGGYVDSI LP
//
