ID A0A1G4WVK9_9MYCO Unreviewed; 464 AA.
AC A0A1G4WVK9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=cystathionine beta-synthase {ECO:0000256|ARBA:ARBA00012041};
DE EC=4.2.1.22 {ECO:0000256|ARBA:ARBA00012041};
DE AltName: Full=Beta-thionase {ECO:0000256|ARBA:ARBA00030337};
DE AltName: Full=Serine sulfhydrase {ECO:0000256|ARBA:ARBA00031579};
GN ORFNames=HZU40_29395 {ECO:0000313|EMBL:QNJ92234.1}, SAMN02799620_04966
GN {ECO:0000313|EMBL:SCX29974.1};
OS Mycolicibacterium fluoranthenivorans.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=258505 {ECO:0000313|EMBL:SCX29974.1, ECO:0000313|Proteomes:UP000199707};
RN [1] {ECO:0000313|EMBL:SCX29974.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC267MFSha1.1M11 {ECO:0000313|EMBL:SCX29974.1};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000199707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UNC267MFSha1.1M11 {ECO:0000313|Proteomes:UP000199707};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QNJ92234.1, ECO:0000313|Proteomes:UP000515498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2A {ECO:0000313|EMBL:QNJ92234.1,
RC ECO:0000313|Proteomes:UP000515498};
RA Chen W., Faulkner N., Smith C., Hyman M.;
RT "Draft genome sequence of four isobutane-metabolizing strains capable of
RT cometabolically degrading diverse ether contaminants.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine;
CC Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001175};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family. {ECO:0000256|ARBA:ARBA00007103}.
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DR EMBL; CP059894; QNJ92234.1; -; Genomic_DNA.
DR EMBL; FMUB01000011; SCX29974.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4WVK9; -.
DR STRING; 1502745.SAMN02799620_04966; -.
DR Proteomes; UP000199707; Unassembled WGS sequence.
DR Proteomes; UP000515498; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004122; F:cystathionine beta-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro.
DR CDD; cd01561; CBS_like; 1.
DR CDD; cd04608; CBS_pair_CBS; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR046353; CBS_C.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR005857; Cysta_beta_synth.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01137; cysta_beta; 1.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00291; PALP; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:QNJ92234.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT DOMAIN 340..402
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 464 AA; 48851 MW; 717A48A09370B2D7 CRC64;
MRIARHISDL IGNTPLVQLN SVVPHGAGLV AAKIEYLNPG GSSKDRIAVK MIDAAEASGA
LKPGGTIVEP TSGNTGVGLA LVAQQRGYKC IFVCPDKVSE DKQNVLRAYG AEVVVCPTAV
PPDHPDSYYS VSNRLVEEVP GAWKPDQYSN PNGPASHYET TGPEIWADTD GKITHFVAGV
GTGGTITGTG RYLKEVSGGR VKVIGADPEG SVYSGGTGRP YLVEGVGEDF WPSAYDPTVP
DEIIAVSDAD SFEMTRRLAR EEALLVGGSC GMAVVAALRV AEREGPDAVV VVLLPDGGRG
YLSKVFNDAW MSSYGFLRSR LDGSIEEVTV GHILRRKSGE LPDLVHTHPS ETVRDAINIL
REYGVSQMPV VGAEPPVMAG EVAGSVSERD LLSAVFEGRA KLADAVGDHM GAPLPLIGSG
ELLSTAAKTL RDYDALMVVE DGKPIGVLTR HDLLGSLSDG GFPR
//
