ID   A0A1G4XGE4_9ACTN        Unreviewed;       355 AA.
AC   A0A1G4XGE4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Hemolysin, contains CBS domains {ECO:0000313|EMBL:SCX39758.1};
GN   ORFNames=SAMN03159343_0773 {ECO:0000313|EMBL:SCX39758.1};
OS   Klenkia marina.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Klenkia.
OX   NCBI_TaxID=1960309 {ECO:0000313|EMBL:SCX39758.1, ECO:0000313|Proteomes:UP000198981};
RN   [1] {ECO:0000313|Proteomes:UP000198981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45722 {ECO:0000313|Proteomes:UP000198981};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FMUH01000001; SCX39758.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G4XGE4; -.
DR   STRING; 1960309.SAMN03159343_0773; -.
DR   OrthoDB; 110231at2; -.
DR   Proteomes; UP000198981; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR43099:SF4; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..202
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          221..279
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          283..339
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   355 AA;  37031 MW;  95238ECEAAD4A3AD CRC64;
     MNDVLALAIL VALLLGNAFF VAAEFALVSA RVDQIEPRAA AGSARAQKTL AAMRNVSQMM
     AGAQLGITLC SLGLGAVGEP AVAHLIEVPL EAAGVPAGFL HPVALVIALA LVTVLHMVLG
     EMVPKNITIA GPDRAAIVLG PPMAKVVVLL KPLIWFFNSL ANGFVKLFGV TPTDEVAASF
     DSTEIRSMIT QSRSRGLLGD EVSDLAEGAL TFETHDARSV LLPADTLVTV ARGTTPRQLE
     QVVAEHGFSR YPVCGPGGAW IGYVHVKDVL GSDDRDRPVP DDALDQFVEV APDEPLPEVL
     QTMRRAGVHL GRVAEDDEVL GVVALEDVLE QLIGDVRDAS AEGAAPAVGS GAGGR
//