ID A0A1G4YUM6_9ACTN Unreviewed; 419 AA.
AC A0A1G4YUM6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN03159343_3462 {ECO:0000313|EMBL:SCX56618.1};
OS Klenkia marina.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Klenkia.
OX NCBI_TaxID=1960309 {ECO:0000313|EMBL:SCX56618.1, ECO:0000313|Proteomes:UP000198981};
RN [1] {ECO:0000313|Proteomes:UP000198981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45722 {ECO:0000313|Proteomes:UP000198981};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FMUH01000006; SCX56618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G4YUM6; -.
DR STRING; 1960309.SAMN03159343_3462; -.
DR OrthoDB; 3206505at2; -.
DR Proteomes; UP000198981; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR PANTHER; PTHR44936:SF12; SENSOR PROTEIN CREC; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SCX56618.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..215
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 223..419
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 419 AA; 42362 MW; D7272F76EE8CDBA3 CRC64;
MRRRITLLVA ATTSVVLLAF LLPAAALVSR VAEARALDAA RQQVQTLLPV VALAPGADGV
RTAVDAGLAA GRQVAVVWPD GTVVGDPGAV LPSAVPTTAT TVDVAGGTVV AQPVARDGGT
AVVTVRVPDE VARSGVLRTW LVLGGLGLVL FTLALLVADR LARTLTRPVS ELAATADRLG
HGELTARVEP AGPADIRAVG TAVNRLAGRI GELLAAEREN AADLAHRLRT PLTALRLDVD
ALPTGSARDR LVDDVDELSR TVDAVIADAR RPVREGLQAE SDAAAVVADR VGFWAVLAED
EGRALDVDLV PGPLPVRVPA ADLGAVVDAL LGNVFAHTPA GTPFAVAVRS RPGGGAVVTV
ADRGPGTAAT AAVRRGVSGR GSTGLGLDIA RRAAEASGGS ATVHGDDGTT VVLELGPPT
//
