ID A0A1G5BRT6_9FIRM Unreviewed; 953 AA.
AC A0A1G5BRT6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:SCX92929.1};
GN ORFNames=SAMN02910370_00741 {ECO:0000313|EMBL:SCX92929.1};
OS Lachnospiraceae bacterium XPB1003.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1520825 {ECO:0000313|EMBL:SCX92929.1, ECO:0000313|Proteomes:UP000199543};
RN [1] {ECO:0000313|EMBL:SCX92929.1, ECO:0000313|Proteomes:UP000199543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XPB1003 {ECO:0000313|EMBL:SCX92929.1,
RC ECO:0000313|Proteomes:UP000199543};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FMVK01000002; SCX92929.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G5BRT6; -.
DR STRING; 1520825.SAMN02910370_00741; -.
DR OrthoDB; 9757901at2; -.
DR Proteomes; UP000199543; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199543};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..330
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 611..913
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 953 AA; 106159 MW; 773F0FBC1F44D3B2 CRC64;
MFYDLREKII SFVTSRFLVP FLMLAVIFLV LIARIFKLQI VNGDSYRANF TLSIEKQVNI
PSTRGNIYDR NGELLAYNIL AYSVTITDTI ESGSTKNREL NEIVLKTVDI IEGNGDSVIN
DFGIYLDEDN NFCFSYTGTK HQRFLADIYG KALVSDLSYD QKNANPDMVM SYLCSASKYG
IGAYTGNEGS KVGFIPQMGF TKKQMLDISI IRYNLSLNGF QKYIATTIAS DVSDKTVAEI
MENSDILQGV TITEDTIRKY NHSVYFSQIL GYTGRISEEE YEQYSASDPN YSTNDYVGKT
GIEFSMESEL QGQKGSETIY VDNLGRILET DNVVAPTAGN DVYLTIDTNL QKAVYRLLEQ
KIAGILTSRI VNEKTVNQHG RNRQIPIYDV YYALISNNVI DMKHLSKDYA GTTEQEVLAT
FQSKQADACA QLRKEMTELD TPYCDLTDEY KEYESFIISM LSSSNYGVIL SDKVDVTDEM
YRKWHSEESI SINEYLNYCI SAQWIDLTKL TLDDKYSDSG EIYNALVDYI IDKLATNPDF
SKRLYKYLIM NDMVTGRQLC LILWEQDLIQ VEDDRLEGLR NGSISAYGFM TKLISDIKIT
PAQLGLEPCS GSCVITDPNS SEVLALVSYP GYDNNRLANT ADSAYLAKLG SDRSKPLWNY
ATQQKTAPGS TFKMVSSVAG VEEGVININT VIDCEGSFTK LNGTIHNCWI YPGSHGPLTL
SGAIQNSCNY FFYEVGYRLA DDDGRYNDAY GIERLSKYAT MFGLGQTTGV EIAESEPNIS
DQYPVASAIG QGTHNYTTVG LARYVSAVAN KGTVYQLSLI KEIRNADGVT TYSGKNKIVN
EIMLDPTLWN AIHTGMMRVV ADKKYFNDIG IICAGKTGTA QEAENKPNHA LFVGFAPADK
PKIAMAVRIA NGYSSDFAAQ LGCDVIKYYF NLEDRDKLIT GNASDATVTS AGD
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